Postdoctoral researcher in bioinformatics and single cell sequencing

Do you want to contribute to top quality medical research?

The research at our lab The Reproductive Endocrinology and Metabolism (see http://ki.se/en/fyfa/reproductive-endocrinology-and-metabolism) at the Department of Physiology and Pharmacology aims to yield new key information on the pathophysiology of polycystic ovary syndrome (PCOS). PCOS is linked to multiple severe health consequences, including reproductive, metabolic, and psychiatric disorders. The research is translational, with the overarching objective to dissect the molecular, mechanistic, and causal links that contribute to the PCOS pathology and its transmission across generations.
The group works in an inspiring and interactive research environment in Biomedicum at Campus Solna (see https://staff.ki.se/biomedicum-for-staff) and has on-going collaborative projects with national and international colleagues.

Your mission

The postdoctoral applicant is expected to lead a project that aim to reveal cell-type-specific disease signatures, variations in cellular composition, and mechanisms of PCOS-specific skeletal muscle dysfunctions at single-cell level and to investigate and define the effect of metformin and lifestyle management on single-cell perturbations. The applicant will work with in vitro culture of tissue biopsies collected from an ongoing clinical trial to perform functional molecular analyses.

Your profile

We are looking for a passionate, highly motivated postdoctoral researcher with a PhD degree in bioinformatics, single cell sequencing preferably within the area of reproductive endocrinology, metabolism, developmental programming, molecular biology, or related area. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We expect the candidate to have a strong scientific background with relevant expertise in single cell biology as well as processing and analyzing single-cell sequencing data. We work with high-performance computing (HPC) i.e. UPPMAX and most of our analyses are done with bash, R and/or Python. Experience from handling human tissue samples performing in vitro culture work, siRNA, Crispr/Cas genome editing is a strength.

Priority will be given to the applicant with proven ability to work independently. The person should be a positive team player as postdoc in part will be involved in supervision of master and PhD students in the group. Moreover, good communication skills and good proficiency in spoken and written English are necessary and Swedish is a strength.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Biomedicum, Campus Solna
Read more about the Department of Physiology and Pharmacology

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

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