ERC fundend postdoctoral scholarship: Exploring drivers of intratumor heterogeneity and phenotypic plasticity - Hiring in process/Finished, not possible to apply

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The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Division

The Schlisio lab at Karolinska Institute, Sweden, seeks a postdoctoral fellow to work on molecular principles of tumor formation arising from the sympathoadrenal cell lineage (neuroblastoma, pheochromocytoma, paraganglioma) to explore cell of origin, disease initiation and tumor heterogeneity.

Duties

We are seeking a motivated, creative post-doctoral candidate interested in exploring drivers of intratumor heterogeneity and phenotypic plasticity in sympathoadrenal tumors, such as childhood neuroblastoma and pheochromocytoma.

Intratumor heterogeneity and high plasticity account for therapy resistance. Causes of plasticity cell state transitions during tumor progression remain poorly understood. Currently, there is no effective treatment that addresses cancer heterogeneity. Systematic characterization of dynamic properties of intratumor heterogeneity and phenotypic plasticity can guide treatment strategies and improve clinical outcome for cancer patients. We aim at elucidating the origin and heterogeneity of sympathoadrenal malignancies, such as pheochromocytoma and childhood neuroblastoma by developing a new analytic and experimental approach based on single-cell transcriptomics with integrated mass spectrometry. We generated novel tumor mouse model systems and include human tumors to perform comparative differentiation trajectory analysis, to make predictions and, finally, to perform preliminary validations of envisioned tumor differentiation strategies.

For more information about the group see: https://ki.se/en/mtc/schlisio-lab

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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