Postdoctoral reseracher in cellular and molecular immunology - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Our lab studies cellular and molecular mechanisms of cell fate decisions in the immune system with a focus on two areas: transcriptional regulation of these decisions and development and function of innate-like lymphocytes (Kreslavsky et al, Nat Immunol, 2017; Rauschmeier et al, EMBO J, 2019; Dunst et al, JLB, 2020; Glaros et al, Immunity, 2021; Rauschmeier et al, J Exp Med, 2022). This project will focus on the latter direction, specifically – on the biology of gamma-delta (gd) T cells – arguably the least understood cell type of the adaptive immune system.

Your mission

The focus of the lab is on mechanisms of cell fate decisions in the immune system. The research program will be shaped to take into account interests of the candidate. Funding for the position is secured, but the successful candidate will be encouraged to apply for fellowships. 

Your profile

We are seeking one or two highly motivated postdoctoral researchers with a strong desire to study principles of immune system function. Passion for science and desire to work hard for its progress are the main requirements. The candidates applying for this project must have a PhD degree in biomedicine, immunology, cell biology or a related discipline. Knowledge of immunology and experience with some of the relevant experimental approaches (e.g. flow cytometry, mouse work, molecular biology techniques, scRNA-seq and bioinformatical analysis of scRNA-seq datasets) are beneficial. Emphasis will be placed on personal compatibility with lab members.  Applicants must have good English skills, good communication skills and ability to collaborate effectively and work productively in a team.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the research team of Taras Kreslavsky. The successful candidate will join an international team of enthusiastic researchers. Stockholm is a vibrant international megapolis with one of the highest quality of living standards in the world. Virtually everyone in Stockholm can speak English and English is the only working language of the group. The Karolinska Institute is one of the centers of excellence for biomedical research in the world (ranked as 8th in the world in Life Sciences and Medicine by QS World University Ranking). It possesses cutting edge infrastructure including facilities for flow cytometry, microscopy, NGS sequencing (the institute is one of the world leaders in single cell RNA-Seq) and transgenic technologies.

Selected recent publications of the PI

Rauschmeier, R.*, Reinhardt, A.*, Gustafsson, C., Glaros, V., Artemov, A.V., Dunst J., Taneja, R., Adameyko, I., Månsson, R., Busslinger, M. #, and Kreslavsky, T. # (2022) Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis. Journal of Experimental Medicine.

Glaros V. *, R. Rauschmeier*, A.V. Artemov*, A. Reinhardt*, S. Ols*, A. Emmanouilidi, C. Mirabello, Å.K. Björklund, L. Perez, N.P. King, D. Angeletti, K. Loré, I. Adameyko, M. Busslinger, and T. Kreslavsky. (2021) Limited access to antigen drives the generation of early B cell memory while restraining the plasmablast response. (* - equal contribution) Immunity.

Dunst, J., Glaros, V., Englmaier, L., Sandoz, P.A., Önfelt, B., Kisielow, J., and Kreslavsky, T. (2020) Recognition of synthetic polyanionic ligands underlies “spontaneous” reactivity of Vγ1 γδTCRs. Journal of Leukocyte Biology.

Rauschmeier, R., Gustafsson, C., Reinhardt, A., A-Gonzalez, N., Tortola, L., Cansever, D., Subramanian, S., Taneja, R., Rossner, M.J., Sieweke, M.H., Greter, M., Månsson, R., Busslinger, M., and Kreslavsky, T. (2019). Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity. The EMBO Journal.

Kreslavsky T., B Vilagos, H. Tagoh, D.K. Poliakova, T.A. Schwickert, M. Wohner, M. Jaritz, S. Weiss, R. Taneja, M.J. Rossner, and M. Busslinger. (2017). Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nature Immunology.

https://ki.se/en/meds/team-taras-kreslavskiy

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications 
• Motivation letter clearly explaining why you are interested in joining our lab for this project.

The application is to be submitted through the Varbi recruitment system.

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