1 postdoctoral position with focus on computational analysis of spatial omics in multiple sclerosis

The research group

Come and join the research group led by Professor Goncalo Castelo-Branco, Karolinska Institutet, Stockholm, Sweden. In the Castelo-Branco lab, we are particularly interested in the molecular mechanisms defining the transcriptomic and epigenomic states of oligodendrocyte lineage cells, with the aim to design novel therapies to prevent and treat neuroinflammation and promote remyelination in multiple sclerosis. We are looking for 1 postdoctoral fellow interested in working in this area.

Our research group has performed single-cell/spatial omics studies, identifying for instance several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019, Nature Biotechnology 2021, 2022, Neuron 2022, Nature 2023, Cell 2024,among others). Our recent findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought, transitioning for instance to disease-associated states. The postdoctoral project will focus on the computational analysis of spatial omic technologies. The successful candidate will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists and neuroimmunologists.

Skills and personal qualities

We are looking for a highly motivated, driven, inquisitive, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidates should have a strong collaborative approach to research, be a team player as capable of working independently and contribute to a good social environment in the laboratory. The applicants must have a PhD degree, and either strong experience in spatial cell omics and programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science and big data.

To be eligible for a postdoctoral position, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology. This Unit has presently eight research groups, focused on omics technologies and several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertise, and vibrant scientific environment. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

1. A complete curriculum vitae, including date of PhD defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work (nor more than 4 pages)
2. A selected list of publications (no more than 2 pages)
3. A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page)
4. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)

Want to make a difference? Join us and contribute to better health for all