Research Specialist in Normal and Malignant Megakaryopoiesis - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

The Department of Medicine, Huddinge conducts preclinical and clinical research in a variety of areas and undergraduate and graduate education. The department is internationally oriented and consists of seven units with about 40 teams.

Description of the subject area

The Jacobsen lab comprises an international collaborative team focused on understanding at the single cell level the cellular and molecular pathways governing the earliest fate decisions in normal hematopoiesis (Carrelha, J., et al., Nature 2018; Sanjuan-Pla, A., et al., Nature 2013; Luis, T.C., et al., Nat Immunol 2013; Boiers, C., et al., Cell Stem Cell 2013) and how these are dysregulated in hematologic malignancies (Booth, C.A.G., et al., Cancel Cell 2018; Giustacchini, A., et al., Nat Med 2017; Woll, P.S., et al., Cancel Cell 2014; Mead, A.J., et al., N Eng J Med 2012; Tehranchi, R., et al., N Eng J Med 2010). This is studied in mouse models, as well as in relevant patients. Key technologies applied towards these research questions include high-throughput DNA and RNA sequencing including single cell analysis, genetic fate-mapping using next-generation-sequencing technology, flow cytometry, mouse genetics and various in vitro and in vivo stem cell assays. The postholder will have the opportunity to lead projects focused on the use of single cell functional assays and genetic fate-mapping (e.g. see our recent paper in Nature [Carrelha, J., et al., Nature 2018].

Your mission

The researcher will drive a project with focus on unravelling the lineage commitment pathways from multipotent hematopoietic stem cells to megakaryocyte-restricted progenitors, and how this process is dysregulated in preleukemic and leukemic hematopoiesis.

The project will largely focus on studies in mouse models.

Applicants are expected to take the lead on a high-profile research project through active pursuit of relevant experiments, and through regular interactions with the group leader and important collaborators.

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

The applicant should have a strong track record (including evidence of one or more high impact first author publications) in studies of normal and/or dysregulated megakaryopoiesis. This is a requirement to be considered for this position.

Extensive experience working with mouse models of megakarypoiesis and platelet development is required.

Good knowledge of spoken and written English is required.

Assessment criteria

It is particularly meritorious that the applicant has shown

• Training in international leading laboratories is a merit as is a background.
• Excellent interpersonal and communication skills, organizational skills to plan experimental bench-work and the ability to work as part of a team as well as independently when required. Ability to stay on top of the relevant research field is an absolute requirement.
• After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Read more about the Department of Medicine, Huddinge (MedH)
Read more about Jacobsen research group 

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 2022-10-31

The application must be submitted through the Varbi recruitment system.

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