Do you want to contribute to improving human health?

The research group

The position is in the Rare Diseases research group. We study genetic disorders on a molecular level in order to understand disease mechanisms and apply new knowledge to genetic diagnostics. We work in a modern laboratory at the Bioclinicum building situated within the grounds of the Karolinska University Hospital, Solna. Several group members also work at the Department of Clinical Genetics at the hospital, the largest clinical genetic department in Sweden with 90 employees working with genetic diagnosis and counseling. We also work closely with the Science for Life Laboratory in Solna, and thus have access to massively parallel DNA sequencing (MPS) with all available technologies. We are currently developing in vitro and in vivo modeling assays to evaluate genetic mutations detected in patients.

The doctoral student project and the duties of the doctoral student

We are looking for a motivated person with a background in molecular biology and genetics and an interest to work with bioinformatics. The selected applicant will help to establish robust techniques to investigate causes behind congenital syndromes and childhood cancer predisposition. The applicant will be involved in WGS panel 30x germline analysis, WGS trio analysis, reanalysis of WGS data, transcriptome analysis and functional studies of new candidate genes and model organisms. This project provides the opportunity to participate in a large national translational research project within Genomic Medicine Sweden/Barntumörbanken (GMS/BTB) about Childhood Cancer Predisposition that will have direct clinical impact

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Eligibility requirements for doctoral education

In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents
Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills and personal qualities

A degree within the area of biomedical research or corresponding area is required.

We are seeking a new group member with a broad range of interests and expertise in the following key areas:

1) Knowledge of basic molecular techniques including nucleic acid extraction PCR, qPCR, CRISPR editing, Western blot, immunohistochemistry

2) Basic and advanced knowledge of cell culture, including fibroblasts, iPSCs and other cell lines

3) Basic programing skills

4) Good writing skills

5) Administrative skills

Terms and conditions

The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process

Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents. We prefer that your application is written in English, but you can also apply in Swedish:

- A personal letter and a curriculum vitae 
- Degree projects and previous publications, if any 
- Any other documentation showing the desirable skills and personal qualities described above 
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)

Selection

A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.
- Personal suitability is also an important criterion.

 All applicants will be informed when the recruitment is completed.

https://ki.se/en/mmk/rare-diseases

Want to make a difference? Join us and contribute to better health for all

Type of employment PhD placement
Contract type Full time
Salary Månadslön
Reference number STÖD 2-4451/2020
Contact
  • Ann Nordgren, Professor, 08 5177 67 18
Union representative
  • Virpi Töhönen, SACO, virpi.tohonen@ki.se
  • Elisabeth Noren-Krog, OFR, elisabeth.noren-krog@ki.se
Published 16.Oct.2020
Last application date 29.Oct.2020 11:59 PM CET

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