Do you want to contribute to top quality medical research?

Karolinska Institutet is one of the world's leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Division
We are seeking a highly motivated postdoctoral researcher in bioinformatics to join a consortium of two research teams dedicated to understand the function of 3D epigenome folding and its deregulation in human diseases from entirely novel perspectives. The candidate is expected to drive a postdoctoral project and participate in collaborative efforts to uncover hitherto unknown therapeutic targets in complex diseases, such as cancer. The work will be carried out at the department of Oncology and Pathology in the labs of Drs Anita Göndör and Rolf Ohlsson. We have innovated state-of-the-art techniques enabling the analysis of 3D chromatin structures and chromatin fibre networks in single cells and small cell populations to provide unique opportunities for novel discoveries.

For further information about our work, please consult a selection of reports from our labs: Nature genetics 51: 1723-1731 (2019); Science 359:1212-1213 (2018); Mol Cell 59:984-97 (2015); Nature Review Genetics 17:284-99 (2016); Nature 2009; Sumida et al, BioRxiv 2018 doi: https://doi.org/10.1101/286583

Duties
The successful applicant will employ state-of-the-art bioinformatic techniques adapted to the analyses of single cells, and join a lab currently consisting of 4 PhD students, 7 postdocs and four affiliated professors.

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements
In addition, it's advantageous if the successful candidate has:

  • Experience in the analysis of NGS data, in particular: RNA-seq, single cell RNA-seq, ChIP-seq, 3C-based chromatin interactome datasets
  • Experience in network analysis
  • Excellent knowledge in biostatistics
  • Extensive experience in using R/BioConductor, Unix/Linux environment (prior scripting language experience e.g. Python/Perl is a plus)
  • Experience in data visualization
  • Experience in meta-analysis
  • Experience in SNP calling from NGS data is a plus
  • Proficiency in written and spoken English
  • Good understanding of biological concepts and/or willingness to learn
  • Experience in working with wet lab scientists

A high level of organizational and communication skills, as well as an ability to independently perform experiments and implement interpretation of data is mandatory.

Location: Solna BioClinicum

https://ki.se/en/onkpat/anita-gondors-group

https://ki.se/en/onkpat/rolf-ohlsson-lab

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Reference number 2-844/2020
Contact
  • Rolf Ohlsson, rolf.ohlsson@ki.se
  • Anita Göndör, anita.gondor@ki.se
Union representative
  • Andreas Lundqvist, SACO, 08-517 768 84
  • Helen Eriksson, OFR, 08-524 823 38
Published 17.Feb.2020
Last application date 01.Mar.2020 11:59 PM CET

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