Postdoctoral researchers in mitochondrial metabolism

Do you want to contribute to top quality medical research?

The group of Dr. Anna Wredenberg and Dr. Christoph Freyer is looking for 2 highly motivated postdoctoral researchers to work in the area of mitochondria to study post-translational modifications. We recently identified several novel modifications on mitochondrial proteins and are now keen to understand their function and isolate the corresponding modifying enzymes. For this, the group uses a combination of model organisms, molecular biology, and large-scale data analysis.

Division

The Wredenberg lab is part of the Division of Molecular Metabolism at the Karolinska Institute, which aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The laboratory offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The Division of Molecular Metabolism also closely interacts with the Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory). The current research includes biochemical and genetic studies of patients with inherited metabolic diseases, as well as basic scientific approaches to understand mechanisms and regulation of mtDNA gene expression. Additionally, the division is interested in metabolic changes caused by mitochondrial dysfunctions and their molecular consequences. Both patient material (tissues and cells) and genetically modified model organisms (fruit flies and mice) are used in these studies. The overall aim of the division is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatment strategies.

Research group

We use a range of model systems, including genetically modified fruit flies and mice, as well as patient-derived and reprogrammed cell lines, to broaden our understanding of the molecular interactions that affect mitochondrial metabolism, both in health and disease. Our research aims at identifying the molecular consequences of metabolic derangements, caused by inborn errors of metabolism, specifically those involving mitochondrial dysfunctions. Additionally, we have a special focus on identifying and understanding posttranscriptional and posttranslational modifications within mitochondria and how they regulate mitochondrial and cellular function.

For more information about the group, please visit: www.wredenberglab.com

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Campus Solna

Your profile

Applications are invited from individuals of the highest calibre with a Ph.D. degree. A strong background in molecular biology and/or mouse or Drosophila genetics is required. Knowledge in mitochondrial biology is preferred, but not essential. A working knowledge of the English language is required. Personal suitability is of great importance when evaluating the applicants.

A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

Application

An employment application must contain the following documents in English or Swedish:

A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)
Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)
Contact information of two references, recommendation letters are also welcome
A brief letter of motivation (no more than one page)

Welcome to apply at the latest December 23^rd

The application is to be submitted through the Varbi recruitment system.

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