Postdoctoral studies in Immunology (scholarship)

Do you want to contribute to improving human health?

This Postdoctoral Fellow position in the Division of Immunology, Department of Medical Biochemistry and Biophysics (MBB), will be part of Professor Qiang Pan-Hammarström's research group. The group conducts research on the genetics of inborn errors of immunity, B cell biology, B-cell lymphomagenesis and immunotherapy. It consists of several PhD students, postdoctoral researchers, and senior scientists. We offer a stimulating scientific environment and a top research infrastructure both locally, at the department level, and institution level.

Division

We are interested in studying adaptive immunity, focusing mainly on B cell development and immunoglobulin gene diversifications in the context of inborn errors of immunity. We are seeking a highly motivated Postdoctoral Fellow with a strong background in basic immunology and molecular medicine, particularly in investigating genetic mechanisms underlying inborn errors of immunity associated with antibody deficiency and other types of adaptive immune defects in humans.

Duties

We are looking for a highly skilled and motivated candidate who is interested in applying new technologies and tools to investigate the mechanisms underlying human inborn errors of immunity and to validate novel disease-causing genes. In this position, you will work closely with our multidisciplinary team of researchers, including clinicians, biotechnologists, and bioinformaticians. The ultimate goal is to gain deeper insights into how we can improve diagnosis and treatment of patients with immunodeficiency, whether in the context of infection, allergy, autoimmunity and cancer. To achieve this, the team is working with a well-characterized cohort of genetically defined patients[HM1] . The main responsibility of the successful candidate will be to conduct mainly functional assays, including handling human samples, immunological profiling, cell culture, genome editing, single-cell sequencing, multi-omics analysis, and other relevant functional validation assays.

Entry requirements

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.

To be eligible for appointment, the candidate must hold a PhD in immunology or related biomedical fields, and have experience in transcriptome/proteome expression assays, site-directed mutagenesis, advanced cell culturing, multicolor/spectral flow-cytometry and cell sorting. For the current position, priority will be given to candidates with documented experience in performing standard molecular and cell biology assays, generating iPSC and organoid models, applying CRISPR/Cas9 based gene knockout or other base/prime editing methods for human cells, such as T and B cells, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells, and conducting single-cell multi-omics analyses.

The applicant must be detail-oriented and capable of working efficiently in a collaborative, interdisciplinary, research environment. In addition to taking the lead and advancing a specific research project(s), it is expected that the candidate will contribute to common laboratory duties and participate in the supervision of research students. Fluency in written and spoken English is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location:

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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