Postdoctoral position in Computational Structural Biophysics

Do you want to contribute to top quality medical research?

Protein Dynamics and Mutation Lab

Department of Oncology-Pathology

The “Protein Dynamics and Mutation Lab” strives to contribute to biomedical research integrating simulations and experiments at different scales. Our goal is to understand the structural and conformational mechanisms of cancer and disease mutations. We are team of passionate scientists at the cross-roads of structural and computational biology. Our research is performed in an interdisciplinary setting with strong collaboration with experimentalists in other departments and other national and international groups. Approximately 300 people from over 40 nations are currently working at the Department of Oncology-Pathology in about 30 research groups with cancer research profiles spanning from very basic to translational and clinical research.

Your mission

Your main role will be to perform a broad range of multiscale computational analyses of potential cancer targets, and develop coarse-grained methods for the characterization of mutations. As a more senior member of a new research group, you will have the chance to play a bigger leadership role and mentor MSc and internship students, while also benefiting from direct supervision and collaboration with a young PI. You will have the opportunity to work with significant freedom and independence within an interdisciplinary as well as an international setting, participating in the setting up of a new lab.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

We are looking for a highly motivated postdoctoral researcher in structural bioinformatics to join our research team dedicated to understand the effects of mutations from a structural and dynamical perspective. The candidate is expected to participate in collaborative efforts to develop a workflow for multiscale screening of cancer and disease mutations, integrating and developing different coarse-grained and atomistic simulation methods.

Advanced knowledge in structural bioinformatics and proven experience with molecular simulation tools (GROMACS, CHARMM, etc) and/or multiscale and coarse-grained approaches, such as Normal Mode Analysis, Brownian Dynamics, etc. are a prerequisite. Extensive expertise in Elastic Network models in cartesian and ideally, also internal coordinates, is mandatory. The applicant must be well acquainted with programming & scripting languages common in molecular modelling. Previous experience with protein simulations, knowledge of complimentary structural analysis techniques (Network Analysis, PCA, etc) and additional modelling and simulation methods will be highly valued.

Fluency in English, a high level of organizational and communication skills, as well as an ability to work independently, is mandatory. The candidate is also expected to take a strong lead in managing project(s), contribute to writing manuscripts and grants and mentor junior members of the team.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: KI Solna Campus

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 30^thApril.

The application is to be submitted through the Varbi recruitment system.

This position is for 2 years, with possibility of extension.

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