Karolinska Institutet

Karolinska Institutet, Institutionen för medicin, Huddinge

Established in June 2013, the Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KIAZ ICMC) represents a unique and exciting opportunity for academic scientists to collaborate and work side-by-side with scientists from the pharmaceutical industry to discover and develop the next generationof medicines to treat cardiovascular and metabolic diseases. More information about AZ/KI ICMC can be found at http://ki.se/en/medh/integrated-cardio-metabolic-centre-icmc

Description of the research group
The central scientific interest of Myriam Aouadi’s lab is to understand the interaction between the immune system and metabolism at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human metabolic disease. We use several different approaches to study immunometabolic diseases, including next generation sequencing, gene manipulation and in vivo systems. 

Responsibilities
We are seeking an experienced candidate with an extensive background in experimental laboratory work. Applicants should be familiar with experimental methods and in particular able to work with mice and with the most common molecular biology techniques.
In addition to the entry requirements, the candidate will be working with the group leader to jointly develop and organize laboratory functions including group meetings and ordering of lab-related items.
You will work closely with researchers and assist in the introduction of the laboratory for new staff, guest researchers and graduate students as well as with the development and improvement of experimental methods. 

Entry requirements and duties

  • Must hold a MSc or a PhD in medical science
  • Strong expertise working with mice
  • Documented experience with animal experimentation (FELASA certification)
  • Excellent in vitro laboratory skills (qPCR, westernblot, library preparation, ELISA)
  • Excellent experience working with sequencing techniques (library preparation for RNA-seq, scRNA-seq)
  • Histology, immunohistochemistry, RNAscope and confocal microscopy experience
  • Experience in training people
  • Ability to maintain KLARA database and working with AGRESSO system
  • Ability to maintain good relationship with the department and animal facility as well as with external collaborators
  • Supervision of the lab members
  • Support of all the projects in the lab
  • Strong ability to negotiate with sales representatives
  • Excellent organizational skills
  • The applicant must speak and write fluent English and display excellent communication skills 

Meriting

  • Documented and extensive training in mouse models of metabolic diseases and isolation of macrophages from liver and adipose tissue
  • Experience in writing applications for ethical permits
  • Administrative and management skills
  • Emphasis will be placed on personal qualities as responsibility, flexibility, teamwork and ability to solve problems.
  • Strong leadership

Application process
This is a substitute position with an initial phase of 10 months.

The application is to be submitted on the Varbi recruitment system.

An application must contain the following documents in English: 

  • Curriculum vitae
  • A personal letter
  • Two references
Type of employment Temporary position
Contract type Full time
First day of employment As soon as possible
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-205/2019
Contact
  • Myriam Aouadi, myriam.aouadi@ki.se
Union representative
  • Belinda Pannagel SACO, belinda.pannagel@ki.se.
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
Published 15.Jan.2019
Last application date 29.Jan.2019 11:59 PM CET

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