Postdoctoral researcher in biologics for targeting diseases of the nervous system

Do you want to contribute to top quality medical research?

Are you looking for a job in an inspiring and international research environment?
We are looking for someone to work with us to develop a biologic way to treat neurodegenerative disease. We are seeking a postdoc to the department of Biosciences and Nutrition, https://ki.se/en/bionut/department-of-biosciences-and-nutrition, which is located in the Neo building on the south campus of KI in Flemingsberg.

Your mission

The postdoc will be working in the laboratory for protein misfolding and assembly at BioNut, https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly, currently consists of one professor, two assistant professors, two senior research specialists, three post-docs and three PhD students. We have discovered how a molecular chaperone domain (BRICHOS) prevents cell toxic effects of protein misfolding and shown in cell and animal models that recombinant BRICHOS passes the blood brain barrier (BBB) and has potential to treat neurodegenerative diseases, including Alzheimer´s disease (AD) (Mol Ther 2023, RSC Med Chem 2023, Prot Sci 2023).

Protein misfolding and aggregation is a cause of disease, and self-assembly into amyloid fibrils is linked to devastating human diseases including AD, which poses an urgent social-economical challenge for the society. Major research efforts have been undertaken to understand the disease pathophysiology, and to develop disease-modifying therapies, but novel approaches are urgently needed. Recombinant BRICHOS domain prevents neurotoxic effects of several amyloid proteins and passes the BBB, which makes it a realistic and attractive agent to harness for various applications in neurodegenerative disorders. The aim of this project is to translate these findings to medical applications.

The position is for 2 years, with the possibility of extension.

Qualifications

PhD in medicine, biochemistry, biomedicine, cell or molecular biology, or another relevant field.
Documented experience of cell and animal experiments, immunochemistry, and similar techniques.
familiar with animal (mouse) and cell models
Excellent communications skills.
Fluency in spoken and written English

Additional merits

Since the position involves close interaction with several researchers, emphasis is also placed on personal skills. The successful applicant should have the ability to work independently and as part of a team, and be open for collaborations. Good data management and documentation skills are also required.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Links: Choose to work at KI – Ten reasons why

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 30 November 2023.

The application is to be submitted through the Varbi recruitment system.

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