Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II

The project: We have an opening for an individual wishing to join a multidisciplinary project aimed to understand the role of lipid mediators in lung disease. Chronic lung disease is one of the largest noncommunicable diseases globally, with 4 million deaths in 2012 alone. The successful candidate will be expected to use and further develop mass spectrometry-based methods for quantification of lipid mediators (e.g., prostaglandins, leukotrienes) and related molecules. Analyses will involve development of novel chromatography approaches including chiral and UPC2 methods for applications in clinical cohorts as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of lung disease. Functional studies will be performed in multiple cell types, in ex vivo lung tissue as well as in animal models to generate a biochemical map of both pro-inflammatory and pro-resolving lipid mediators.

The Environment: The successful applicant will belong to the Integrative Molecular Phenotyping laboratory (http://metabolomics.se) in the Department of Medical Biochemistry and Biophysics. The Karolinska Institute is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. The Karolinska Institute accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at the Karolinska Institute has selected the Nobel laureates in Physiology or Medicine. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers in a new custom designed state-of-the art facility. This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

Qualifications: We are looking for highly motivated candidates with a Ph.D. in quantitative mass spectrometry or bioanalytical chemistry. The successful candidate will be expected to use and further develop mass spectrometry-based methods for metabolic profiling of lipid mediators. Accordingly, applicants must document their experience in small molecule mass spectrometry by LC-MS/MS as well as familiarity with quantification and method validation. Prior experience working with lipids is considered a merit as well as experience in cell culture and FACS analysis. Excellent communication skills and an ability to interact socially and scientifically with other members of the laboratory and with collaborators in various networks are essential.

Entry requirements: A person is eligible for a position as Postdoctoral Researcher if she or he has obtained a PhD or a foreign qualification deemed equivalent to a doctorate, no more than five years before the last date of employment as postdoc. Applicants who have completed their degree no more than three years before the last date for applications will be given priority. Applications consisting of cover letter, full CV and references should be submitted via the KI varbi system. The start date is negotiable, but the selected candidate would ideally begin as soon as possible. Applications will be evaluated as they are received.

Further Information: For additional details of the department and research interests:




Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Type of employment Temporary position
Contract type Full time
First day of employment upon agreement
Salary monthly
Number of positions 1
Full-time equivalent 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-3804/2019
  • Craig E. Wheelock, Ph.D, +46 (0)8 5248-7630
Published 02.Jul.2019
Last application date 03.Nov.2019 11:59 PM CET

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