Postdoctoral Researcher in RNA Splicing in Normal and Aberrant Hematopoiesis

Do you want to contribute to top quality medical research?

We are seeking an ambitious postdoctoral researcher to map alternative RNA splicing programs in normal and aberrant blood formation. This groundbreaking project will use single-cell full-length transcriptomics to create a comprehensive atlas of alternative splicing in human hematopoiesis. You will cutting-edge technologies for translational research with the opportunity to identify patterns associated with adverse outcomes in myeloproliferative neoplasms. The project is most suitable for a postdoctoral researcher with experience in computational analyses.

Your mission

As a postdoctoral researcher, you will:

• Develop and apply bioinformatic methods to analyze alternative splicing events and associate them with cell type, genotype, and clinical outcome

• Identify and functionally characterize aberrant splicing programs associated with disease progression in myeloproliferative neoplasms

• Collaborate with clinicians and other researchers within the group and publish results in leading scientific journals

Your profile

To be eligible for employment as a postdoc, a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.

We are looking for candidates with:

• PhD in bioinformatics, computational biology, genetics, or related field

• Expertise in genomic data analysis, particularly single-cell RNA-sequencing and/or alternative splicing

• Strong background in bioinformatics and programming skills (e.g., Python, R)

• Understanding of RNA biology and alternative splicing

• Excellent communication and collaboration skills

• Ability to work independently and take initiative

It is advantageous if you have:

• Hands-on experience with experimental single-cell RNA-sequencing

• Knowledge of hematopoiesis and hematological diseases

• Experience working with clinical samples

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

As a postdoc in this project, you will be part of KIRI, the Karolinska Institutet Research Incubator, a unique initiative at KI to build a community for interdisciplinary research and breakthrough discoveries. You will have access to two PI:s that you can meet and interact with to facilitate the research process and increase the synergetic effects. You will also have the opportunity to meet other KIRI postdocs, present your work at scientific events, and take part in KIRI activities. Read more about KIRI here: research/ki-research-incubator-kiri

This position is a collaborative project between Christoph Ziegenhain and Joakim Dahlin and will be co-supervised by both.

You will work in:

• A dynamic and supportive research environment with access to state-of-the-art single-cell genomics technology

• Two groups with expertise in hematology, genomics, and bioinformatics

• Close collaboration with clinicians and access to patient cohorts

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

• A complete list of publications

• A summary of current work (no more than one page)

Welcome to apply at the latest 26th January 2026

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!