Research engineer in protein production/molecular biology - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We are seeking a highly skilled and motivated research engineer in protein production/molecular biology to join an international open science effort in translational medical research. This is an exciting opportunity to work on generating proteins and antibodies to human targets as part of the EUbOPEN project, using a combination of molecular biology, cell biology and biochemistry. We offer a multi-national and collaborative research environment with partners in academia and the biomedical industry worldwide.

Your mission

A highly skilled, motivated and experienced research engineer (or with equivalent experiences) in protein production/molecular biology is needed to work at SGC-Karolinska in our IMI (EU and Pharma) funded EUbOPEN project. You will be part of a research team developing high quality protein affinity reagents. Specifically, you will generate recombinant antibodies using phage display selection and characterize prioritized human proteins, to serve as e.g. tool reagents for assay development, antigens for antibody production, analysis of protein interaction partners and to aid crystallization experiments. You will be an integral member of the team which works to generate high quality and renewable antibodies in a high throughput format. The work includes cloning, protein production, phage display selection and cell-based antibody validation. The duties of the position includes reporting and data dissemination (via publications and public data repositories). Thus, your work will contribute to the broader goal of EUbOPEN; to make pharmacological tools to one third of the human druggable genome, available to the scientific community without restrictions, as part of the Target 2035 initiative.

Project

This large-scale project is a collaboration between the Karolinska Institutet, University of Oxford (UK), Goethe University Frankfurt and other partners in EU, UK and globally, funded by the European Union and pharmaceutical company partners. EUbOPEN is conducted as an integrated project with the SGC. The EUbOPEN organization based at Karolinska Institutet comprises funding for more than 20 staff members and is expected to grow as additional funding becomes available. Overall, EUbOPEN has activities e.g. in structural and chemical biology, antibody production and characterization as well as functional studies of human proteins in disease relevant assays. EUbOPEN is funded until end of April 2025 and the right candidate will have a good chance of extension

Eligibility requirements

The successful candidate should have strong expertise in molecular biology and protein chemistry, biochemistry, cell biology or other relevant area(s) and a passion for practical laboratory work. You are a flexible problem solver who likes to work collaboratively as well as independently with production, analysis and reporting of data to the project team. Experience from protein production, antibody generation and validation, designing and running biochemical assays and characterization of proteins is a requirement, and you are familiar with state-of-the-art technologies and instrumentation to perform such tasks. Furthermore, you need to communicate well in English, be well-structured and take responsibility to produce well-documented high-quality scientific data. A documented and solid experience of mammalian protein expression and purification is a distinguishing merit.

Your profile

It is particularly meritorious that the applicant has shown:

 Experience with cloning, expression screening, protein production, protein purification, phage display, antibody validation and cell-based assays and publication track-record. A track-record in mammalian expression of human proteins is considered a significant merit.

It is meritorious that the applicant has shown:

 Experience from studies in the disease areas inflammation and/or fibrosis with a documented publication track-record.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the Department of Medicine Solna which since March 2015 is one of the partners of the Structural Genomics Consortium (SGC, www.thesgc.org) and its Innovative Medicines Initiative (EU) projects which in part focus on the discovery and evaluation of novel targets in inflammatory diseases (ULTRA-DD 2015-2020 and EUbOPEN 2020-2025, www.eubopen.org). The position is placed within the SGC-KI research team headed by Michael Sundström (Scientific Director); organized within the group of Professor Per-Johan Jakobsson, Division of Rheumatology. Part of the work will be carried out in close collaboration with Science for Life Laboratory (www.scilifelab.se).

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

The application must be submitted through the Varbi recruitment system.

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