Postdoctoral Researcher in NK cell biology

Do you want to contribute to top quality medical research?

Our research group seeks to develop new strategies for cell-based immunotherapy based on insights into the functional regulation of NK cells. Through partnerships with leading NK cell groups in Europe and the US, as well as the biotech industry we design and run clinical trials for patients with cancer. At the Center for Infectious Medicine at the Karolinska Institutet you will find a stimulating research environment with the vision to be a world-leading translational research center within immunology. Read more about us below:

https://ki.se/en/medh/kalle-malmberg-group-natural-killer-cell-biology-and-cell-therapy
https://ki.se/en/medh/center-for-infectious-medicine-cim

Your mission

The Malmberg Lab is located in Stockholm/Sweden and Oslo/Norway and currently consists of 24 people. We are now looking for a highly motivated post-doc with an interest in molecular immunology and experimental immunotherapy. The project concerns the differentiation of human NK cells from inducible pluripotent stem cells (iPSC), with a particular focus on directed differentiation into effector cells with desired phenotype and function. One central element is to use our synthetic biology platform to improve the persistence and boost the cytotoxic potential of iPSC-derived NK cells. This project is carried out in close collaboration with our US-based industrial partner Fate Therapeutics and the Malmberg Lab at Oslo University Hospital. The postdoctoral fellow will be required to execute a variety of single-cell assays, including high-dimensional immune profiling by flow cytometry, single-cell indexed FACS-sorting and RNA Seq. The project also involves molecular biology/cloning, transient transfection / overexpression, retroviral and lentiviral transduction in mammalian cells. Additional tasks include gene-editing of iPSC, primary NK cells / NK cell lines by CRISPR/Cas9, cytotoxicity assays, and qPCR. The postdoctoral fellow is expected to plan, execute, and analyze experiments in an independent manner and contribute scientifically to the group.

Your profile

The candidate must hold a PhD equivalent to a Swedish doctoral degree in the fields of immunology, cell- or molecular biology/life sciences, with publications in internationally renowned peer-reviewed journals. The candidate should be self-motivated, have good communication skills and ability to interact effectively and work productively in a team. Candidates should have a strong, documented background in single cell-based assessment of immune cells and experience in flow cytometry, functional immunological assays and preferably translational research. Previous work in molecular biology and genetic engineering, long-term culture and iPSC work is an advantage. In connection with the appointment of the postdoc position, we will accord special weight to academic skills; particularly demonstrated excellence in research, a strong dedication and excellent communication skills. Fluency in English is a requirement.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Choose to work at KI – Ten reasons why

Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest April 30th 2022.

The application is to be submitted through the Varbi recruitment system.

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