Postdoctoral research fellow

Do you want to contribute to top quality medical research?

A postdoctoral position, funded by a grant from the Swedish Foundation for Strategic Research is immediately available to study the role of global transcription factor activity in cellular lineage determination within the laboratory of Professor Jussi Taipale who heads research groups at Karolinska Institutet, University of Cambridge and University of Helsinki. This position is based at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet.

The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology and as such the research groups consist of both experimental biologists and computer scientists. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer and validation of identified elements using cultured cells and mouse genetic models (see for example Hallikas et al., Cell 124:47-59, 2006; Kivioja et al., Nature Methods 9:72-74, 2011; Sur et al., Science 338:1360-1363, 2012; Jolma et al., Cell 152:327-339, 2013; Yan et al., Cell 154:801-813, 2013; Jolma et al., Nature 527:384-388, 2015; Yin et al., Science 356: eaaj2239, 2017; Zhu et al., Nature 562: 76-81, 2018; Jolma et al., Genome Research 30: 962-973, 2020). The applicant benefits greatly from knowledge and expertise of a lab working at the cutting edge of science.

Your mission

The goal of the project is to apply the ATI technique developed in the lab (Wei et al., Nature Biotechnology 36: 521-529, 2018) to build a repertoire of critical TFs that specify different cell fates and use this information for trans-differentiation of cells. The project requires that the applicant has excellent skills in lab work and is familiar with computational analysis of experimental data.

Your profile

The successful candidate should be highly motivated and have a doctoral degree or a foreign qualification deemed equivalent to a doctorate in Systems Biology, Molecular Biology, Biological engineering, Medicine or similar along with computational experience for analysing large sets of data. We especially encourage applications from those who expect to complete their PhD within one year from current date and those who have completed their PhD less than 12 months ago. Applicants must be able to work independently and have good communication skills in English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

(https://www.taipalelabs.org/)

Application

An employment application should be a maximum of 7 A4 pages in total and must contain the following documents in English:

One-page cover letter highlighting your 2 most important first-author publications in major international scientific journals
Two-page CV including a list of major publications (reference only, no abstracts or full papers)
Two letters of recommendation, 1-2 pages each

Welcome to apply at the latest 2020-12-20

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all