Postdoctoral Researcher in Cancer Biology and Therapeutics

Do you want to contribute to improving human health?

The Department of Oncology-Pathology conducts basic, translational, and clinical research together with educational activities related to cancer. The position is placed within the research team of Assistant Professor Sean Rudd and will investigate cancer cell metabolism and its relationship to cancer biology and chemoresistance.

Your mission

The research team of Assistant Professor Sean Rudd is seeking to recruit a postdoctoral researcher. Dr Rudd’s team conducts multidisciplinary research with the goal of improving treatment outcome for cancer patients. This newly started research group, housed within the well-established laboratory of Professor Thomas Helleday, has obtained generous funding from the Swedish Research Council, the Swedish Cancer Society, the Swedish Childhood Cancer Foundation, and Karolinska Institutet, which should secure its activities in the future. Dr Rudd’s team is placed within SciLifeLab, a national centre for molecular biosciences containing state-of-the-art high-throughput technology platforms together with world-leading research labs focused upon cancer biology, chemical biology, and precision medicine, amongst other topics.

Project description

The project is centred upon investigating metabolic pathways inside cancer cells, with a particular focus upon genome stability and nucleotide pool metabolism, and the relationship of these pathways to cancer biology and chemoresistance. The successful candidate will employ an array of biochemical, molecular and cell biology-focused approaches, together with cross-disciplinary collaborations, to fulfil the translational research goals of this project, which is to ultimately improve cancer treatment.

See Dr Rudd’s group page for more information, together with selected publications:

Rudd et al., 2020, EMBO Mol Med
Herold et al., 2017 Nat Med
Tsesmetzis et al., 2018, Cancers
Rudd et al., 2016, DNA Repair

Your profile

We are looking for an ambitious, highly motivated and independent postdoctoral researcher (recent graduate) with a solid background in molecular biology and/or biochemistry.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the intended date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Other requirements of the position include:

Keen interest in translational cancer research and enzyme function
Publications/preprints in the field of genome stability or nucleotide metabolism
Well-versed with standard molecular and cell biology techniques
Experience with characterising recombinant proteins
Effective communication skills – written and oral. Fluency in English.

Desired skills:

Experience in assay development and high-throughput experimental approaches
Experience in cancer drug discovery
Experience in bioinformatics

This employment is for two years for a start, with good possibility of extension.

What do we offer?

A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: SciLifeLab, Solna

Your career continues here

Application

An employment application must contain the following documents in English:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of previous and current work (no more than one page)
A motivation letter
Contact details of 3 scientists that could provide reference letters

Welcome to apply at the latest 2020-05-23.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all