Karolinska Institutet, Department of Clinical Neuroscience

The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with other research groups from the Karolinska Institutet, with other universities as well as the Stockholm County Council.
Please visit our website for more information: ki.se/en/cns

Division
The Department of Clinical neuroscience and the research team of Pete Williams offers an exciting opportunity for a Research Assistant in the field of translational neurobiology. The current project goal is to elucidate the early molecular mechanisms of glaucoma, a common neurodegeneration affecting ~80 million patients worldwide. The overall goal of the Pete Williams Lab is to develop clinically translatable neuroprotective strategies for glaucoma focusing on neuronal metabolic and mitochondrial health.

Current, ongoing projects are investigating how age and elevated intraocular pressure (both major risk factors for glaucoma) intersect to drive neuronal mitochondrial dysfunction and neuronal metabolic decline in glaucoma using animal (mouse and rat), tissue, and cell culture models. Initially, the work is focusing on strategies to reduce retinal ganglion cell vulnerability in glaucoma by targeting neuronal NAD-levels. This is achieved by using genetic, molecular, neurobiological, viral gene therapy, and electrophysiological techniques. By identifying key molecules and mechanisms that render retinal ganglion cells vulnerable in glaucoma, the project will contribute to the development of new diagnostic biomarkers and clinically translatable therapeutics.

The Pete Williams Lab is situated at St Erik Eye Hospital, Kungsholmen, Stockholm, and the hired applicant will have the chance to interact and work in an international environment with multidisciplinary basic research scientists, clinicians, and research clinicians.

Please see also: https://ki.se/en/people/petewi and https://petewilliamslab.comfor more information on projects and access to relevant primary literature.

Duties
Daily duties include, but may not be limited to:

  • Colony management (mouse and rat) and drug treatment regimes
  • Assistance with surgical procedures; rodent ophthalmological clinical exams
  • Cell and tissue culture
  • Molecular biology techniques such as immunofluorescence, Western blotting, qPCR, genotyping/PCR
  • Microscopy and image analysis

Entry requirements
We are looking for an ambitious research assistant with enthusiasm towards bettering human health through basic and translatable neurobiology. The successful candidate must have a Bachelor’s degree with a strong background in either neuroscience, ophthalmology/visual sciences, biomedical sciences, or molecular biology and wet-lab experience. A Master’s degree or additional wet-lab knowledge would be highly advantageous.

Previous practical experience with rodent husbandry, molecular biology techniques, basic neuroscience techniques, and/or microscopy techniques are considerable substantial merits.

Good English skills are a requirement.

Application process
The application is to be submitted in Varbi recruitment system.

Type of employment Tijdelijk dienstverband langer dan 6 maanden
Contract type Full time
Number of positions 1
Working hours 100 %
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-933/2019
Contact
  • Pete Williams, Assistant professor, pete.williams@ki.se
  • Anna Wendel, HR Administrator, anna.wendel@ki.se
Union representative
  • Arsalan Amir, SACO, 08 - 517 733 37, arsalan.amir@ki.se
  • Venus Azhary, OFR, 0707-124 127
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 21.Jan.2019
Last application date 11.Feb.2019 11:59 PM CET

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