Institutionen för medicin, Solna, Clinical Immunology and Allergy Unit

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several divisions that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Research group
The Allergy and Immunology Unit at the Department of Medicine, Solna performs research on different aspect of allergy and autoimmune diseases. Our research group (PI: Eduardo Villablanca) will develop new in vivo models to study the function of genes associated with autoimmune diseases, such as inflammatory bowel diseases (IBD). In particular, we aim to establish zebrafish as an in vivo model to study cellular process affected during IBD with the final goal to translate this knowledge to mouse model and eventually to human. Our group works in an inspiring and interactive research environment at the Karolinska University, Solna and has ongoing collaborative projects with national and international colleagues.

Duties
Beside “gut-centric” conditions, such as inflammatory bowel diseases (IBD), emerging evidence indicate that disruption of intestinal homeostasis have systemic consequences. Hence, understanding the gut as a place of immune cell education will give us important insights into the etiology of diseases, including extra-intestinal disorders. The main goal of this project is to investigate how trafficking and development of DC and/or ILCs contribute to maintain intestinal homeostasis. The successful candidate will utilize newly generated genetically modified mouse models to investigate the requirements of novel candidate genes in trafficking to intestinal tissues. Comparison between genetically-modified mice and wild type mice will be carry out using state-of-the-art technology such as single cell RNA-seq and CyTOFF. The candidate will eventually validate her/his finding using human samples. The postdoctoral fellow is expected to work independently, to take the responsibilities of the design, execution, organization, report and development of the research project.


Entry requirements
Our lab has an opening for a highly creative and motivated postdoctoral scientist with an interest in mucosal immunology. We look for a candidate with documented laboratory research experience particularly in mouse models of intestinal inflammation, human myeloid cells and CD4+ T cells biology, culture in vitro and multi-parameter flow cytometry in the context of mucosal immunology. Experience in bioinformatics and RNA-seq analysis would be an advantage. The position will require independent work at the laboratory as well as extensive collaboration with clinicians and other experimental groups. Fluency in both oral and written English is necessary. Documented ability to analyze and present results orally and written is important. Additional requirements include outstanding communications skills and the ability to generate new ideas and innovate.

Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstances

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoctoral scholarship
Contract type Full time
Reference number 2-2590/2017
Contact
  • Eduardo Villablanca, 073-628 22 89
Union representative
  • Lars Ährlund-Richter, SACO, 08 - 5177 34 50, lars.ahrlund@ki.se
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
Published 23.May.2017
Last application date 14.Jun.2017 11:59 PM CET

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