Postdoctoral research fellow in Translational Lung Cancer Research

Do you want to contribute to top quality medical research?

The Department of Oncology-Pathology at Karolinska Institutet conducts basic, translational and clinical research and educational activities related to cancer. The position is placed in the research laboratory of Associate Professor Simon Ekman. The group of Associate Professor Simon Ekman focuses on the development of novel treatments for lung cancer. The overall aim is to develop new oncological treatments through the approach of personalized cancer medicine.

Your mission

The candidate is expected to play a major role in molecular analysis, scientific hypothesis generation, presentation of results and manuscript preparation. The candidate will work on several projects regarding coding and non-coding RNAs, including microRNAs, and their role in acquired resistance to tyrosine kinase inhibitors. The duties involve routine cell biology work and establishment of molecular methods, as well as computational and biostatistical analyses of expression array data. The candidate will be working closely together with a senior wet lab molecular biologist, to ensure high quality output from all steps.

The position covers the following main tasks:

Taking responsibility for cell culture duties to generate and maintain non-small cell lung cancer cell lines resistant to various tyrosine kinase inhibitors
Taking responsibility for performing reproducible and robust wet lab experiments, including RT-qPCR, Western blotting, viability assays and 3’UTR reporter assays
Performing bioinformatics analyses of RNA profiles from large expression array data
Handling and extracting material from clinical lung cancer specimens
Being involved in the design and planning of wet lab experiments

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We are looking for an experienced postdoc-level candidate who recently completed his/her PhD. The candidate should be a careful and detail-oriented person who likes to take responsibility. The candidate should be capable of close internal cooperation, as well as interacting with external collaborators that are experts in a wide variety of fields connected to our research. For this, excellent communication skills are required. The candidate should have a strong desire to deliver high quality work, on time, and have experience in working independently.

In addition, applicants must have:

Documented experience in working with bioinformatics tools for large expression-based array analysis, including NanoString
Extensive experience with various cell culture techniques, including troubleshooting
Documented experience with RNA extraction, RT-qPCR, and viability assays, including troubleshooting
Documented experience with microRNA-based methodologies, including troubleshooting
Documented experience in working with tyrosine kinase inhibitors, including troubleshooting
Documented experience in working with clinical samples, including RNA profiling from clinical specimens
Excellent oral and written communication skills
Fluency in English

Furthermore, it is beneficial if applicants have:

Experience in other molecular biology methods, not mentioned above

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 2022-11-25.

The application is to be submitted through the Varbi recruitment system.

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