ONE POSTDOCTORAL RESEARCHER IN CANCER BIOLOGY - Hiring in process/Finished, not possible to apply

Do you want to contribute to improving human health?

The “Genome Integrity” group at the Karolinska Institutet - SciLifeLab, led by Prof. Jiri Bartek has one postdoc vacancy.

Our research focuses on various mechanistic aspects of the DNA replication, DNA damage response and DNA repair pathways. Of particular interest is discovery of targets and markers of replication stress and features useful for personalized cancer treatment, including discovery of novel components or mechanisms of genome integrity maintenance. Another of our long-term goals is to unravel the principles of ribosome biogenesis and protein translation control and to understand how ribosomal stress crosstalks with the DNA damage response. See also recent publications from the research group including Björkman A, et al Genes Dev. 34: 1065-1074, and Espinoza JA, et al Cell Death Diff. 27:  773-789.

For further information visit https://ki.se/en/mbb/jiri-bartek-group

Division/Research group 

Our group is integrated at the Division of Genome Biology, together with other competitive groups that work in areas such as epigenetics, genome stability, advanced imaging or genomics (https://ki.se/en/mbb/research-division-of-genome-biology).

Apart from other competitive grants, our team has obtained generous funding from the Swedish Research Council that secures its activities in the long term.

At SciLifeLab, our group is intertwined with other world leaders in various areas of molecular biosciences, and has access to national facilities for proteomics, next generation sequencing, chemical biology, drug discovery and development, among others. The research lab is well equipped with state-of-the art microscopes and other imaging tools.

Your mission

We are seeking a highly motivated, creative post-doctoral candidate interested in exploring the role of nuclear envelope components in genome integrity and response to oncogene activation. In the long term, we aim at elucidating the involvement of the nuclear envelope in disease processes, particularly during cancer development.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We are currently looking for a highly motivated postdoctoral scientist to join our team with a Ph.D. in Cell Biology, Molecular Biology or other relevant fields. The applicant should have extensive experience and deep knowledge in the area of cancer cell biology and deep hands-on experience in different molecular biology techniques, such as site-directed mutagenesis, quantitative RT-PCR, Western blot, flow cytometry, co-immunoprecipitation, DNA combing, iPOND, DRIP, comet assay or high-throughput fluorescence microscopy. Knowledge of and hands-on experience with DNA replication and replication stress (including electron microscopy of replication intermediates), imaging (including atomic force microscopy), construction of cell models with regulatable expression of oncogenes, mass spectrometry (especially SILAC approach), antibody development, and mechano-biology techniques related to genome integrity and ribosome function, would be advantages. The successful candidate should have a strong publication record, it is expected that the candidate has the capacity to independently develop scientific research projects and a documented ability to obtain competitive funding, preferably at the international level. Complete fluency in both written and spoken English is a requirement. 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: SciLifeLab, Solna Campus

Choose to work at KI – Ten reasons why

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest October 14th 2022.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all!