A postdoctoral Researcher in translational research on leukemia niche - Extended application time - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Division

Center for Hematology and Regenerative Medicine (HERM) is a research unit within the Department of Medicine Huddinge with a focus on bringing together basic and clinical competences to pursue cutting-edge research improving the understanding of mechanisms involved in normal and malignant hematopoiesis. The ultimate goal is to translate novel scientific findings into the clinic, thereby improving patient outcome.

Description of the project

The vision of Hong Qian’s group is to unraveil the role of mesenchymal niche in leukemia with the aim of identifying novel molecular pathways mediating the interactions between leukemic cells and their niche during leukemia progression and treatment response.  The ultimate goal is to identify novel niche-based therapeutic targets for better treatment outcome of diseases.

The group so far has been mainly focusing on the mesenchymal niche in myeloid leukemia in patients and mouse models. The main technologies used include multi-color flow cytometry, confocal imaging, lineage tracing, in vitro coculture, experimental transplantation and advanced molecular tools including RNA sequencing, digital PCR and single cell PCR.

Duties and requirement

We are looking for a highly self-motivated person with a strong background in cellular and molecular biology with a keen interest in leukemia microenvironment. Experience in working with tumor microenvironment, molecular and cellular biology techniques, multi-color flow cytometry, confocal imaging and mouse modeling is highly desired; and good ability to communicate in English (written and verbal) is required. The successful candidate will conduct the research with a special focus on deciphering molecular pathways mediating leukemic stem cell interaction with their niche under the supervision of the group leader (Dr. Hong Qian). In addition, the candidate is expected to participate in several collaborated project throughout her/his postdoc training.

The candidate will be working a collaborative environment and will be given the opportunity to participate in national and international scientific meetings. Additionally, the candidate is expected to participate in supervision of junior students in the group.

It is considered as a merit if the applicant has experience in laboratory animal work (as documented by FELASA C or equivalent) with at least three years hands on experience working with mice.

The position will be funded for 24 months, with a possibility of extension of 2 additional years.

Entry requirements

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest 2021-03-19.

The application is to be submitted through the Varbi recruitment system.

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