Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism

Division of Molecular Metabolism
Applications are invited for the postdoctoral position in the group of Joanna Rorbach, at the Division of Molecular Metabolism, Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KIL) located at Karolinska Institutet, Stockholm.

 he Division of Molecular Metabolism (http://ki.se/en/mbb/research-divisionof-molecular-metabolism, http://ki.se/en/mbb), is located in Biomedicum, Solna campus of Karolinska Institutet. The research at the division aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mtDNA expression and other aspects of mitochondrial metabolism. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments.
The Division of Molecular Metabolism offers an outstanding research environment and a close interaction between basic science, clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory (https://www.scilifelab.se).

Research background
Mitochondria are sub-cellular organelles essential for eukaryotic cell function, and their dysfunction has been implicated in a variety of hereditary diseases, ageing, cancer and immunity. The correct expression of mitochondrial DNA is essential for mitochondrial function. Currently, we try to understand mechanisms of gene expression in mitochondria; as a means to identify the pathways and factors important to human mitochondrial diseases and improve our understanding of the fundamental mechanisms of eukaryotic cell function. More specifically, we focus on: i) RNA-protein interactions in mitochondria; ii) mitochondrial ribosome biogenesis; iii) molecular and structural characterization of the mitochondrial translation machinery. We employ diverse model systems and multidisciplinary approaches and to address these questions, including cryo-EM, high-throughput gene targeting, proteomics and RNASeq-based ribosome profiling.
For further information about the project and the position, please contact Dr Joanna Rorbach, e-mail: Joanna.rorbach@ki.se.

Successful applicant requirements
Enthusiastic and motivated applicants should have a strong background in molecular or structural biology. Specific experience in mitochondrial biology is an advantage, given the nature of the research, but is not a requirement. The successful applicant should be knowledgeable of biological advancements, demonstrate a promising publication record, and have a rigorous scientific approach. The candidate should be able to work independently and interactively in a team and collaborative settings, as our research group collaborates with several laboratories within Sweden and abroad.
A person is eligible for this position, if he or she has obtained a PhD no more than four years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Two references (name and contact information)

The application is to be submitted through the Varbi recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-2679/2019
  • Joanna Rorbach, 08-524 866 93
Union representative
  • Anne Edgren, OFR/S, P, O, 08-524 87570
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75
  • Henry Wölling, SEKO, 08-524 840 80
Published 02.May.2019
Last application date 02.Jun.2019 11:59 PM CET

Retour aux postes vacants