Postdoctoral position in immunology – EU-funded project on T cell immunity against respiratory viruses

Do you want to contribute to improving human health?

We are looking for an ambitious postdoctoral fellow with solid human immunology skills to join our EU-funded project (REACT) on cell-mediated immunity against respiratory viral infections. We offer an international collaborative environment in a rapidly moving research frontier. The successful candidate will be part of the EU cluster of researchers working at Karolinska Institutet (KI) and Denmark Technical University (DTU).

Your mission

Within the EU consortia, we (Dr. Marcus Buggert, KI, and Dr. Sine Reker Hadrup, DTU) oversee the human studies on virus-specific T cell immunity. These studies are translational and involve using cutting-edge barcoding single-cell technologies, including high-parameter flow cytometry, RNA-seq, TCR-seq, proteomics, and gene-editing analysis to dissect the heterogeneity and function of memory T cell immunity.

The postdoctoral candidate will work with immunological questions centered on respiratory tract infections, including SARS-CoV-2, Influenza A, and RSV. The fellow will work in close conjunction with researchers at DTU during the first year(s) and use next-generation barcoding technologies to decipher similarities and differences in how T cells recognize different respiratory viruses after vaccination and infection. The candidate will also work in close collaboration with various members of the group at KI to set up barcoding and other single-cell technologies to dissect different functions of human memory T cell biology in viral disease. As such, we are seeking a postdoctoral candidate with a Ph.D. in the field of T cell immunology who will work as an integrated member of our teams at KI and DTU, with the capacity to implement new technologies to drive his/her own projects forward.

Your profile

To be eligible for employment as a postdoctoral candidate, the candidate should have demonstrated research expertise and documented research experience in human and/or T cell immunology during or after the Ph.D. defense. A strong candidate should preferably have a solid background in studies of human T cell biology in viral infections, e.g., SARS-CoV-2. Experience in sequencing techniques, flow cytometry, and virus-specific T cell technologies will also be considered merits. Applicants should have first-author publications in recognized peer-reviewed journals. Fluency in English is a requirement.

It is particularly meritorious that the applicant has

Been trained in immunology during her/his Ph.D. studies
Publications in the field of human T cell immunology
Extensive knowledge in multiparametric flow cytometry
Antigen-specific T cell staining (e.g., tetramers, intracellular cytokines)
Extensive BSL-II cell culture background
Next-generation sequencing skill sets (e.g., preparation of RNAseq libraries)
Basic molecular biology techniques (e.g., PCR)
Statistical knowledge

It is meritorious that the applicant has

Trained in biotechnology/biomedicine during her/his Master’s studies
Bioinformatics analysis of single-cell flow cytometry and sequencing data

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-11-03

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all