Researcher in single-cell immunology

Do you want to contribute to top quality medical research?

We are looking for an ambitious Researcher with solid single-cell immunology skills to join our highly accomplished team of translational immunologists. We offer a stimulating environment in a rapidly moving research frontier.

Your mission

The Mjösberg group (https://mjosberglab.wixsite.com/ilcs and https://ki.se/en/medh/jenny-mjosberg-group studies the development, regulation and function of innate lymphoid cells (ILCs) in humans and how these cells contribute to pathology in mucosal organs such as the lung and gut. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms and therapy targets. The group is internationally recognized as a leader in the field through several high impact publications in recent years (Nat Immunol 2016, Nat Comm 2020, Cell Res 2021 etc).

The researcher will continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq) to dissect human intestinal mucosal ILC and T cell biology in health and disease. The successful candidate will be part of a team in an ongoing project that involves dissection of gut-associate lymphoid tissues from human intestinal specimens and generation of scRNA-seq (SMARTseq and 10X genomics) data as well as multicolor flow cytometry data of human mucosal ILCs and T cells from these tissues. The data will be analyzed in close collaboration with bioinformaticians. As this is a team effort, excellent communication skills are essential, as is proven ability to work in multidisciplinary teams. It is expected that the researcher will contribute to supervision of students and other researchers if necessary, with ambitions to become a primary supervisor and develop a related independent line of research by obtaining external long-term funding.

Your profile

In addition, the applicant should have a minimum of 4 years of postdoctoral experience carrying out high quality immunological researcher in dynamic research environment. Any candidate must also be able to demonstrate pedagogical skills as supervision is an important aspect of this position.
The candidate must hold a PhD equivalent to a Swedish doctoral degree in the field of immunology. The candidate must fully master multidimensional (>20 parameters) flow cytometry analysis and sorting, as well as be experienced in scRNAseq. Experience in the dissection, isolation and in vitro culturing of primary immune cells from mucosal tissues is a requirement, as is basic functional in vitro assessments of immune cell function such as intracellular cytokine stainings, ELISA etc. The candidate should be familiar with R software and have some experience analyzing scRNAseq data and downstream pipelines such as Gene Set Enrichment (GSEA). The candidate should have a strong publication track-record. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdiciplinary team. Fluency in English is a requirement as well as some basic skills and willingness to learn Swedish.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 2021-03-02.

The application is to be submitted through the Varbi recruitment system.

Permanent position are initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all