Postdoctoral Researcher in neurodegenerative disease mechanisms with focus on Alzheimer disease therapy - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

Division and project
Karolinska Institutet and the Division of Neurogeriatrics perform research on different aspects of Alzheimer disease and other neurodegenerative disorders from molecules to patients. The division has around 80 employees and is situated both at Campus Flemingsberg and Campus Solna.

The project aims to explore novel therapeutic concepts for Alzheimer disease (AD) based on regulation of function of molecular chaperones or other systems responsible for intracellular protein folding and degradation. The project involves studies of biological effects using human cells and AD animal mouse models. The position will be located at BioClinicum at the KI-Campus-Nord. The Swedish Research Council (VR) is funding this project. We are looking for a postdoctor to join the project for one year with possibility of extension.

Your mission
You are expected to have a strong drive to pursue experimental research, and an ambitious and innovative attitude. The project is pursued in collaboration with other researchers why documented good collaborative skills are necessary. Good ability to speak and write English is also a requirement.

The position involves analysis of potential drugs that target processes relevant for AD and other neurodegenerative diseases. Specifically, the function of regulatory components and potential drugs will be assessed in cell lines and mouse models, which are related to AD. Alzheimer disease and other neurodegenerative diseases are associated with aggregation of certain proteins such as beta-amyloid and tau. This project focuses on tau aggregation by development of small molecule ligands, targeting protein- protein interaction. In particular, we combine structural biology techniques such as computer aided drug design, biochemical and biophysical methods to develop novel ligands as potential drug candidates for AD. We also investigate biological effects of these molecules and validate them in proof-of-concept experiments. The duties include in silico drug design using virtual screening, hit-to-lead compound development, lead optimization, development of biochemical assays for compound screening.

Your profile
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.
You must have a PhD in (bio) medicine, cell biology, biochemistry or similar topic.
Documented experience with cell and animal models in neurodegenerative diseases is qualifying, including scientific publications in this research area. You should master the above described, required technologies.

What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest January 3 2020.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all