Karolinska Institutet, institutionen för fysiologi och farmakologi

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Research Group and Project Description
Tumor cells display metabolic profiles that are remarkably distinct from their normal tissue of origin. This is to ensure fulfillment of their higher bioenergetic/biosynthetic needs required to support rapid proliferation.
Tumor cells display metabolic profiles that are remarkably distinct from their normal tissue of origin. This is to ensure fulfillment of their higher bioenergetic/biosynthetic needs required to support rapid proliferation. Less is known about metabolic heterogeneity in seemingly identical cancer cells. We have previously identified metabolic heterogeneity in lymphomas that can be rationally targeted (Cancer Cell. 2012, Cell Death Differentiation. 2017) and more recently in lung adenocarcinomas (Cell Reports, 2017, Journal of Cancer, 2017). Our group focuses on understanding fundamental mechanisms underlying metabolic heterogeneity. Hence, we are currently trying to identify molecular regulators that shape the tumor metabolism and metabolic diversity, with the ultimate goal of identifying novel drug targets and biomarkers.  
For more information please see our published work:

Cell Reports 2017 Jun 13;19(11):2289-2303)

Journal of Cancer 2017;8(11):2088)

Cell Death Differentiation. 2017 Feb;24(2):251-262 .

Cancer Cell 2012 Oct;22(4):547-60.

Duties
The candidate will conduct research within the field of biochemical cancer research with a focus on tumor metabolism. We seek exceptional, dedicated, self-motivated and hardworking individuals with a positive attitude and with substantial experience in molecular biology or biochemistry or cell biology. The candidate should have a strong background in cancer biology and have a strong track record (as shown by first-author publications in international peer-reviewed journals).  

Entry requirements
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements
The candidate must have hands-on experience with:

  • - Mammalian cell culturing techniques incl. siRNA/overexpression techniques.
  • - SDS-PAGE, Western blot, Quantitative PCR

Desired skills

  • - Experience using an Extracellular Flux Analyzer (Seahorse technology)
  • - Flow cytometry and Confocal and imaging techniques
  • - Experience in proteomics and/or metabolomics.

The candidate should be able to thrive and deliver results on goals in a fast-paced, dynamic and highly multi-tasking environment. The candidate is expected to contribute to scientific discussions and presenting outcomes to colleagues beyond maintaining detailed and organized records of project data and other materials as needed. Strong verbal and written communication skills in English are required.

Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Uploaded Reference letters from, at least, two previous employers with contact information.

The application is to be submitted on the Varbi recruitment system.

Reference number 2-5065/2019
Contact
  • Erik Norberg, erik.norberg@ki.se
Union representative
  • Göran Engberg, SACO, 08-524 867 17
  • Henry Wölling, SEKO, 08-524 840 80
  • Niklas Andersson, OFR, niklas.andersson@ki.se
Published 14.Oct.2019
Last application date 24.Nov.2019 11:59 PM CET

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