Postdoctoral studies on Bruton’s Tyrosin Kinase – from inhibitors to gene correction

Do you want to contribute to improving human health?

This postdoc position will offer the opportunity to join a translational research team to work on aspects of Bruton’s Tyrosine Kinase (BTK) ranging from the use of BTK inhibitors for treatment of lymphoid malignancies to curative gene correction in immunodeficiency patients. The postdoc will work in the interphase between Associate professor Robert Månsson and Professor Edvard Smith’s groups at Karolinska Institutet and Clinical teams at Karolinska University Hospital. The successful candidate will join our team at the Department of Laboratory Medicine at Karolinska Institutet.

Duties

The postdoc position will be within a translational research constellation study aspects of  Bruton’s Tyrosine Kinase (BTK) biology ranging from understanding the in vivo effects and efficacy of BTK inhibitors in patients with lymphoid malignancies, to the BTK inhibitor effects on the tumour microenvironment in model organisms, and the curative gene correction of immunodeficiency patients carrying mutations in the BTK gene. The candidate is expected to participate in experimental design, logistics, sample processing, experimentation, data analysis, documentation, presentation and publication of results. The candidate is expected to work as a bridge between the groups in the translational research constellation. In addition, the candidate is expected to join research-related activities such as group meetings, departmental seminars, national/international meetings, as well as take part in routine work within our research team and help supervise students within the group.

Entry requirements

We are seeking a highly motivated postdoctoral researcher with a strong desire to pursue translational research focused on Bruton’s Tyrosine Kinase (BTK) central role in the treatment of lymphoid malignancies using BTK inhibitors and taking steps towards curative gene correction in immunodeficiency patients. The candidate applying must have a PhD degree in biomedicine, molecular medicine, molecular biology, gene technology, immunology, stem cell biology or a related discipline. 

Expertise in experimental haematology, transplantation models, advanced flow cytometry, sequencing based molecular biology (“omics”) and/or bioinformatics is required to become a successful candidate. Emphasis will be placed on personal suitability and compatibility with lab members and the overall research team. Applicants must have good communication skills in English, be able to drive his/her own project and work within a research team.

Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.

To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.

Location:

The postdoc will be conducted at the Department of Laboratory Medicine at Karolinska Institutets southern campus. The Department consists of seven division working on diverse topics ranging from immunology and theraputic gene correction to pathology and physiology The postdoc will be embedded in the research team of Associate professor Robert Månsson at the Division for Clinical Immunology and in addition work closely with the research team of Professor Edvard Smith as well as clinical constellations at the Karolinska University Hospital. English is the working language of the group. The Karolinska Institutet is one of the centers of excellence for biomedical research in the world (ranked as 8th in the world in Life Sciences and Medicine by QS World University Ranking). Stockholm is a vibrant international city offering a high living standards, access to a sprawling city life as well as the beautiful nature surrounding the city.

https://ki.se/en/research/research-areas-centres-and-networks/research-groups/robert-mansson-group

https://ki.se/labmed/forskning-pa-institutionen-for-laboratoriemedicin/forskargruppsledare-pa-labmed-a-o/enheten-for-molekylar-cellbiologi-och-genterapiforskning

https://ki.se/en/labmed/about-us/divisions

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

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