Research assistant in Experimental Genomics and Gene Therapy

Do you want to contribute to top quality medical research?

The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology. CMB is located in Biomedicum, a new interdisciplinary research center designed to concentrate much of the experimental research conducted at Karolinska Institutet Campus Solna under one roof to promote collaboration. Biomedicum houses approximately 1,200 researchers and other personnel and allows expensive equipment to be shared and utilized more effectively.

The Llorens laboratory offers a vibrant, stimulating and international environment. Our lab uses single cell and spatial genomics technologies with innovative experimental platforms to enable the design of specialized gene therapy constructs to treat central nervous system (CNS) disorders.

Your mission

The research assistant will be an active member of a multidisciplinary team developing experimental pipelines to validate regulatory elements for gene therapy applications.
The successful candidate will contribute to projects aimed at testing gene therapy constructs in relevant cellular and tissue contexts, using both animal models and human patient samples.

Your responsibilities

• Design, cloning, and molecular assembly of gene therapy constructs containing candidate regulatory elements
• Perform in vivo experiments with laboratory animals to generate injury models and deliver therapeutic constructs
• Apply spatial genomics technologies to validate efficacy and specificity of the selected constructs
• Work closely with computational researchers to refine experimental designs based on machine learning-driven predictions

Your profile

We are recruiting a highly motivated and detail-oriented experimental scientist with a strong interest in gene regulation and gene therapy.

Qualifications:

• MSc degree in molecular biology, biotechnology, neuroscience, or a related field (or equivalent laboratory experience)
• Solid hands-on experience in molecular biology, DNA/RNA work, and standard biochemical techniques
• Qualifications to perform rodent research in accordance with institutional and regulatory guidelines are highly appreciated
• Familiarity with single-cell and/or spatial genomics assays is an advantage
• Fluent written and spoken English

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Stockholm

Link to our latest publication: https://www.nature.com/articles/s41593-025-02131-w

Link to our lab page: https://ki.se/en/research/research-areas-centres-and-networks/research-groups/systems-regenerative-neurobiology-enric-llorens-group

[Video about Karolinska Institutet, how we all work towards "a better health for all"]

Application

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Want to make a difference? Join us and contribute to better health for all