Research assistant in lipoprotein metabolism and function

Do you want to contribute to top quality medical research?

The Department of Laboratory Medicine consists of 6 divisions and is active in many areas of Laboratory Medicine to promote human health in short and long term. The department has close collaboration with Karolinska Hospital and is involved in advanced basic scientific, clinical, and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

The ideal candidates will possess a strong educational background in biomedical sciences coupled with extensive practical experience in the laboratory related to lipoproteins. Our group works at the forefront of determining functional metrics of lipoproteins related to cardiometabolic diseases, including atherosclerotic cardiovascular disease, obesity, diabetes and liver diseases.

Your mission

We are seeking a highly motivated Research Assistant with a strong background in biomedical sciences and practical laboratory experience in working with lipoproteins, particularly with respect to metabolism, isolation and determining functional metrics. The successful candidate will contribute to the analysis of HDL functionality from both human samples and mouse models, and work with mass spectrometry to delineate aspects of lipid and protein composition of HDL particles. Combining wet-lab experiments with computational tools will allow to investigate underlying mechanisms that result in disease phenotypes.

Your profile

To be eligible for this position, the applicant is expected to have a solid understanding of how lipid and lipoprotein metabolism is regulated and be familiar with aspects of HDL function as well as the clinical features and therapeutic strategies associated with cardiometabolic diseases. The candidates must hold, or be close to completing, a master’s degree in biomedical science or a closely related field.

An interdisciplinary background spanning biology, biochemistry, physiology, and bioinformatics is highly desirable as is a deep understanding of metabolic and functional aspects of HDL. Advantage will be given to candidates that are in addition experienced in a variety of laboratory techniques, including but not limited to cell culture, PCR, RNA sequencing, immunohistochemistry, HDL isolation, HDL function assays, Western blot, ELISA as well as in working with preclinical animal models. Experience in bioinformatics and programming (R or Python). Experience with human biopsy handling, flow cytometry, mass spectrometry and other omics data generation is advantageous but not mandatory.

The ideal candidates will demonstrate a high level of independence, a collaborative mindset, and a strong interest in interdisciplinary research. Excellent interpersonal skills, effective communication in English, and a proactive, solution-oriented approach are essential.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: 

The position is located within the Department of Laboratory Medicine, KI Campus Flemingsberg within the Division of Clinical Chemistry (Prof. Uwe Tietge).

Application

Welcome to apply at the latest 14 October.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.

The position is fixed-term for a year.

Want to make a difference? Join us and contribute to better health for all