Postdoctoral Position in Normal Hematopoiesis - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We are looking for a highly motivated and talented postdoctoral candidate to take the lead on one or more challenging research projects in the lab of Professor Sten Eirik W. Jacobsen. The research project(s) will be focused on normal hematopoiesis and hematopoietic stem cell biology, and will be funded by existing grants, including from the Swedish Research Council and the Knut and Alice Wallenberg Foundation.

Research Focus and Projects

A main line of research in the Jacobsen lab is focused on understanding the commitment pathways governing lineage fate decisions from hematopoietic stem cells (HSCs) to mature blood cells (references 1-5). This is studied primarily in mouse models. Key technologies applied towards these research questions include genetic fate-mapping, flow cytometry, mouse genetics, and various in vitro and in vivo stem cell assays.  

Projects will be pursued in part at the Center for Hematology and Regenerative Medicine (HERM), and in part at the Department of Cell and Molecular Biology (CMB). The Jacobsen lab has ongoing strong collaborations related to each of the listed projects, at the Karolinska Institutet as well as internationally, and the recruited postdoctoral candidates will benefit from interactions in a highly collaborative network.

Responsibilities

Members of the research group and collaborators interact closely and regularly on each of these research projects which are conducted primarily in mouse models. Key technologies applied towards these research questions include advanced flow cytometry, mouse genetics, high-throughput DNA and RNA sequencing including single cell analysis, and various in vitro and in vivo assays. The postholder must enjoy teamwork and interact well with others, including other members of lab, as well as collaborating scientists. Good English written and oral communication skills are required for regular presentations of data and project plans.

Essential requirements

• PhD degree or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons, your degree may have been completed earlier.
• Experience with mouse models of normal hematopoiesis
• Experience in studies of hematopoietic stem cells
• Strong track record as evidenced by one or more first author high impact publications in the field of hematopoiesis and hematopoietic stem cell biology.
• Training in international leading laboratories.
• Good knowledge of spoken and written English.
• Ability to stay on top of the relevant research field.

Desired requirements

Experience with advanced state-of-the art flow cytometry.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna and Flemingsberg

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work

• A complete list of publications with any shared authorships clearly indicated

• A summary of current work (no more than one page)
• A maximum one page cover letter summarizing motivation for the position and previous experience and research interests
• Names and contact details of three references who are familiar with the applicant’s recent research and training

Welcome to apply at the latest 17 September.

The application is to be submitted through the Varbi recruitment system.

References  

1. Carrelha J., et al., Alternative platelet replenishment pathways initiated by distinct stem cells. Nat Immunol, 2024. 25(6): p. 1007-1019.
2. Carrelha J., et al., Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells. Nature, 2018. 554(7690): p. 106-111.
3. Sanjuan-Pla A., et al., Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Nature, 2013. 502(7470): p. 232-236.
4. Drissen R, et al., Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. Nat Immunol 2016. 17(6): p. 666-676. (Cover article)
5. Luis T.C., et al., Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors. Nat Immunol, 2016. 17(12): p. 1424-1435.

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