Research Assistant in Translational Neuroscience

Do you want to contribute to top quality medical research?

In our research group, led by Andrea Varrone, you will find a unique opportunity to contribute to groundbreaking translational research that combines preclinical mouse studies with clinical findings to better understand treatment strategies for Alzheimer's disease. We offer an engaging and international research environment where you get an opportunity to contribute to high-quality research at an international top level within neuroscience and autophagy.

Your mission

As a research assistant, you will be a central part of an innovative research project investigating the effects of rapamycin treatment on cerebrospinal fluid (CSF) biomarkers in Alzheimer mouse models. You will work under the supervision of Pontus Plaven Sigray in Andrea Varrone's research group, in close collaboration with Associate Professor Per Nilsson's group, who will provide training and expertise in mouse experiments.

Your main duties include:

• Conduct mouse studies with AppNL-G-F/NL-G-F mice and wild-type controls
• Perform CSF sampling from mice (training will be provided)
• Administer treatment through specialized diet or injections
• Perform post-mortem brain analysis and immunohistochemistry
• Analyze biomarkers related to Alzheimer's disease and autophagy
• Document and analyze experimental data
• Actively collaborate with the research group and contribute to scientific publications 

Your profile

We are looking for a highly motivated candidate who shares our passion for translational neuroscience and wants to contribute to the development of new treatment strategies for neurodegenerative diseases.

Essential requirements:

• Master's degree in biomedicine, molecular biology, neuroscience, or related field
• Documented experience working with laboratory mice and animal handling
• Good knowledge of spoken and written English
• Strong interest in neuroscience and translational research
• Precision, independence, and good collaborative skills

Meriting qualifications:

• Knowledge in immunohistochemistry and immunocytochemistry (ICC)
• Experience with Western blot analysis and RNA isolation
• Experience with real-time PCR
• Knowledge of fluorescence microscopy and cryosectioning
• Experience with biomarker analysis
• Knowledge of neurodegenerative diseases, particularly Alzheimer's disease
• Experience with animal tissue dissections
• Basic knowledge in programming (R, Python)
• Laboratory Animal Science certification 

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna

Read more about the Department of Clinical Neuroscience
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Application

Welcome to apply at the latest September 5th, 2025.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Want to make a difference? Join us and contribute to better health for all!