Research Assistant in Stem Cell aging

Do you want to contribute to top quality medical research?

The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during aging and disease. We discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.

Your mission

Your project will utilize human hematopoietic stem cells to identify factors that facilitate stem cell aging by single sequencing, creating xenotransplants using “humanized” mice and in vitro systems to investigate the underlying mechanisms.

Your profile

We are seeking a highly motivated and ambitious individual from universities around the world to join the research team of Assistant Professor Dr. Jette Lengefeld to mechanistically understand novel mechanisms of human stem cells that drive aging. The Lengefeld research group uses hematopoietic stem cells from mice and human bone marrow donations to discover how deregulation of cellular size is connected to aging.

We are looking for a candidate with:

• An attitude to drive own research and work in an intra and inter team fashion
• Soft skills in teamwork, research communication and presentation
• A competence to think logically in biological terms, as demonstrated in research publication
• We put great emphasis on personal suitability.

Special skills and attributes of the applicant:

Mandatory requirements

• Excellent knowledge in English, written and spoken
• Experience in experimental biology for at least 4 months
• Good understanding of molecular biology and genetics

Meritorious qualities 

• A research background in experimental stem cell biology, hematology, sequencing, cell culture and experience working with mice
• Good knowledge of hematopoiesis
• Hands-on experience with cell culture, cell sorting, and advanced flow cytometry
•  Expertise in R and foundations of statistics

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Department of Medicine, Huddinge (MedH) 

Lengefeld research group

Application

Welcome to apply at the latest 2025-07-31.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Want to make a difference? Join us and contribute to better health for all