Research Assistant in Neutrophil Biology

Do you want to contribute to top quality medical research?

Our laboratory is located on the Huddinge campus of the Karolinska Institute. The overall aim of our research group is to develop Neutrophil-based cellular immunotherapies against cancer. Being part of the Center for Hematology and Regenerative Medicine (HERM), we offer a collaborative environment for translational biomedical research.

Your mission

The use of chimeric antigen receptors (CAR) in T cells has transformed the field of cell therapies for some cancers but have not proven efficacious against most solid tumors. We hypothesize that myeloid cells hold the key to unlocking the full potential of anti-tumor immunity. The outlined project initially aims to design different CAR constructs that are specifically adapted to myeloid cells and transduce them into cell lines, which can be differentiated into mature neutrophils. These studies will be performed in human primary cells or cell lines, and potentially humanized mouse models, with goals to develop translational tools for clinical applications. The position is for six months but can be extended by an additional six months pending the completion of the project.

Your profile

The candidate should have a strong interest in immunology, molecular biology and genome engineering and have a master’s degree or equivalent by the time the positions starts.  Experience with cell culture and basic molecular biology tools, such as PCR and cloning, is a requirement. Experiences working with primary immune cell cultures from mouse or human cells are meritorious, including analysis by flow cytometry. Additionally, it is meritorious if the candidate has experience working with Neutrophils. It is expected that the candidate contributes to a collaborative environment in the lab and can meet deadlines and work independently. Fluency in English, written and spoken, is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Harnessing Neutrophils for Precision Cell Therapy against solid tumors – Roland Fiskesund Team | Karolinska Institutet

Choose to work at KI – Ten reasons why

Application

Welcome to apply at the latest 2025-05-02.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Want to make a difference? Join us and contribute to better health for all