Research Assistant in translational immunology

Do you want to contribute to top quality medical research?

The Bryceson laboratory is located on the Huddinge campus of the Karolinska Institute. The overall aim of our research group is to understand cytotoxic lymphocyte biology, in order to explain and better treat severe inborn errors of immunity as well as develop innovative cellular immunotherapies against cancer. Being part of the Center for Hematology and Regenerative Medicine (HERM) and Center for Cellular Cancer Therapy (C33T), we offer a collaborative environment for translational biomedical research.

Your mission

The use of chimeric antigen receptors (CAR) in T cells has transformed the field of cell therapies for some cancers but have not proven efficacious against most solid tumors. We have deciphered pathways for cytotoxic lymphocyte differentiation, including tissue-resident cytotoxic subsets. A current goal of the lab is to dissect cytotoxic lymphocyte function and use insights to maximize the potential of CAR-T cell therapies. The outlined project initially aims to dissect the differentiation and function of differentiated cytotoxic CD8+ T cells. These studies will be performed in human primary cells or cell lines, and potentially humanized mouse models, with goals to develop translational tools for clinical applications. The position is for six months but can be extended by an additional six months pending the completion of the project.

Your profile

The candidate should have strong interest in immunology, molecular biology and genome engineering and have a master’s degree or equivalent. Experience with cell culture and basic molecular biology tools, such as PCR and cloning, is a requirement. Experiences working with primary immune cell cultures from mouse or human cells are meritorious, including analysis by flow cytometry. Additionally, it is meritorious if the candidate has experiences in transcriptional or epigenetic analyses, analyses of high-throughput sequencing data, or experience with other forms of bioinformatical analyses. It is expected that the candidate contributes to a collaborative environment in the lab and has the ability to meet deadlines and work independently. Good knowledge in English, written and spoken, is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna and Flemingsberg

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Hematology Unit/HERM

Application

Welcome to apply at the latest 2025-01-06.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form. 

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all