Research Specialist in Epithelial Regeneration

Do you want to contribute to top quality medical research?

Description of the subject area

Molecular understanding of mechanisms governing tissue repair is key for developing new therapeutic strategies enhancing tissue regeneration. The advertised  position is focused on understanding mechanisms of epithelial regeneration in the mouse esophagus.

Your mission

The current project is centered around an established mouse model of esophageal epithelial regeneration. You will characterize both the cellular and transcriptional injury response, as well as identifying progenitor cell subpopulations contributing to, and molecular mechanisms required for, epithelial repair. You will use a combination of in vivo genetic labelling and tracing of progenitor cells to quantitatively understand tissue regeneration. Furthermore, single-cell sequencing and spatial transcriptomics will be used to identify molecular mechanisms required for tissue repair.

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having a foreign degree deemed equivalent to a Swedish doctoral degree, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

The candidate should have previous experience of clonal lineage tracing data, organoid cultures and transcriptional profiling. In addition, previous experience of analysing spatial transcriptomics data is required.

Assessment criteria

Candidates will be assessed based on their expertise and eligibility. In addition, the selected candidate should fit well into the current research group.

It is particularly meritorious that the applicant has documented experience from the field of epithelial stem cell biology, focusing on the esophageal epithelium. Furthermore, experience working with mouse models of regeneration and quantitative lineage tracing is considered important.

It is meritorious that the applicant shows an interest in developing skills to handle large sequencing data sets and can handle in vitro organoid culture systems.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

--[Video about Karolinska Institutet, how we all work towards "a better health for all"] --

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents:  PhD certificate, resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply!

The application must be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all!