Postdoctoral Researcher in WNT receptor pharmacology

Do you want to contribute to top quality medical research?

In the research group "Receptor biology & signaling" led by Professor Gunnar Schulte, the focus is on G protein-coupled receptors and in particular class F receptors. The work aims to better understand how ligands interact with class F receptors and their coreceptors, how conformational changes are established to activate the receptors and consequently to initiate interaction and activation of intracellular signaling components. Functional selectivity of class F receptors against heterotrimeric G-proteins or other pathways is analyzed in the hope of exploiting the new knowledge therapeutically.

For more information: https://ki.se/en/fyfa/schulte-lab 

Your mission

The research project aims to understand the underlying molecular details of class F receptor activation and communication with coreceptors for future drug development. The project brings together disciplines such as cell biology, pharmacology, biophysics and molecular biology. The highly motivated candidate, with a strong background in GPCR pharmacology, is expected to drive the research project, technical development and concept development from idea to publication. The candidate's broad expertise in wet lab and assay development is expected to serve as a resource to the research team. The candidate will participate in the supervision of master's and doctoral students. In addition to lab work, the applicant is expected to take an active, constructive and developing part in lab management.

Your profile

To be eligible for employment as a postdoctor a phd or a foreign degree deemed to be equivalent to a Swedish phd is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The applicant should have an in-depth background in biochemistry, molecular biology and cell biology with an emphasis on GPCR pharmacology. Solid experience in cell culture, protein biochemistry, resonance energy transfer (FRET/BRET) techniques, ligand binding experiments, cloning, assay design and assay validation is required. Documented experience (previous high-quality publications) with GPCR pharmacology is a requirement.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Biomedicum, Campus Solna

https://ki.se/fyfa

https://ki.se/en/research/research-areas-centres-and-networks/research-groups/receptor-biology-and-signaling-schulte-lab#tab-vad-vi-gr 

Application

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all!