Postdoctoral Researcher in a translational project on Alzheimer pathologies

Do you want to contribute to top quality medical research?

The Per Nilsson lab offers a dynamic and international research environment driven by curiosity. The lab performs preclinical research on Alzheimer’s disease with a focus on protein homeostasis and the intracellular cleaning system autophagy. We use state-of-the-art mouse models exhibiting Alzheimer pathologies to understand disease mechanisms and to test potential compounds in preclinical trials.

Your mission

This postdoc project aims at finding novel therapeutic strategies to treat amyloid and tau pathologies of Alzheimer’s disease. Newly designed compounds will be evaluated in mouse models recapitulating AD pathologies. The efficacy and mechanism of action of the drug candidates will be evaluated both in vitro by biochemical and immunohistochemical means and in vivo by PET and MR.

The position is a temporary employment for two years.

Your profile

To be eligible for employment as a postdoctor a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Particularly meritorious:

• A broad expertise within neurodegenerative diseases including Alzheimer’s and the fields of intracellular protein degradation and autophagy.
• Practical experience working in vivo with mouse models, including the administration of pharmacologically active compounds.
• Excellent skills in basic biochemical and molecular biology techniques including fluorescence microscopy.
• Good team player that takes initiatives and with good written and spoken English proficiency.

Meritorious:

• A solid track record from the PhD and postdoctoral period, preferably in the field of in vivo preclinical Alzheimer research
• Experience with small animal in vivo imaging.
• Experience with presenting research at international scientific conferences.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Choose to work at KI – Ten reasons why

The role of autophagy in Aβ metabolism and neurodegeneration in Alzheimer’s disease – Per Nilsson group

Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply at the latest December 13th 2024.

The application is to be submitted through the Varbi recruitment system.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all