Research Assistant in Spatial Transcriptomics, temporary position

Do you want to contribute to top quality medical research?

The Rydén and Mejhert lab aims to understand how alterations in human white adipocyte function are related to cardiometabolic disorders such as type 2 diabetes, dyslipidemia, and coronary sclerosis. Our group consists of 15-20 members (senior researchers, postdoctoral fellows, PhD/master students, and technical staff) and has all the necessary infrastructure to conduct translational research including a fully equipped preclinical laboratory at NEO and a clinical research unit at the Karolinska University Hospital, Huddinge.

Your mission

Increased white adipose tissue mass is linked to both type 2 diabetes and cardiovascular disease. However, as these two complications often co-exist the contribution of adipose tissue dysregulation to either of these conditions remains unclear. To this end, we have collected a large clinical cohort where participants have been divided according to the presence or absence of type 2 diabetes and/or cardiovascular disease. From these individuals, we have obtained adipose tissue biopsies, which we will use to generate single-nucleus RNA sequencing and spatial transcriptomic data. By jointly analyzing these data together with functional assessment of the tissue and assessments of clinical phenotypes, we will for the first-time link white adipose tissue disturbance to these common and serious cardiometabolic complications. We are now looking for an ambitious research assistant that will perform single-nucleus RNA sequencing and spatial transcriptomic analyses. The work will be undertaken in collaboration with other experts within the group as well as with members of the lab of Patrik Ståhl at SciLife. There will be possibilities to follow-up key findings with wet lab experiments using state-of-the-art methods. The position is for six months but can be extended by six more months pending the completion of the project.

Your profile

The person appointed should have a master’s degree or equivalent. Experience in common programming languages such as R and Python as well as operating systems such as Linux is highly meritorious. It is a clear strength if the applicant has a proven track record in analyzing large datasets and it is expected that the candidate should be able to prioritize tasks, meet deadlines, and work independently. Good knowledge in English, written and spoken, is a requirement.

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

Location: Flemingsberg

Mikael Rydén & Niklas Mejhert lab | Karolinska Institutet

Application

Welcome to apply at the latest 2024-12-06.

The application is to be submitted through the Varbi recruitment system. In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Want to make a difference? Join us and contribute to better health for all