Postdoctoral Researcher in yeast genome engineering

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe.

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes and are passionate about RNA biology (http://pelechanolab.com/).

You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

Are you interested in unravelling the crosstalk between the proteome and the metabolome? Would you like to combine the use of cutting-edge omics technologies with synthetic biology and biochemistry? Come and join us at SciLifeLab.

Your mission

The successful candidate will work on a collaborative project leaded by Dr. Ilaria Piazza. The Piazza laboratory (Piazza Lab) uses mass spectrometry-based approaches to study protein interactions in cell and tissues integrating proteomics and metabolomics data. The Piazza laboratory is based both at the Karolinska Institute in Stockholm (SciLifeLab) and at the Max Delbrück Center for Molecular Medicine in Berlin.

The available postdoctoral position concerns developing and applying novel genetic and biochemistry approaches to study the crosstalk between gene expression and the metabolome. The candidate will work in the context of an ERC project (porteoRAGE) led by Dr. Piazza. The recruited candidate will focus on engineering massive collections of S. cerevisiae strains to enable the study of the allosteric regulation of gene expression. The candidate will the phenotypic information derived from such collection to generate and validate hypothesis. The candidate will integrate different experimental and computational approaches for the completion of the project, including genomics, yeast genetics, high-throughput biology approaches and bioinformatics. The candidate will perform original research in synthetic biology, genomic, proteomics and structural biology, and acquire the required experimental and computational skills necessary for the completion of the project.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate will participate in the general duties of the team and effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment.

Working language is English.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a Swedish doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants to this position should have a PhD in Molecular biology, Biotechnology, Genetics or similar field.

In addition to the above-mentioned requirements for the role:

The successful applicant should have experience interpreting biological data and experimentally testing their hypothesis with a strong interest in interdisciplinary technology development.
Suitable candidates should have extensive experience with yeast genetics and phenotypic characterization.
Research experience with large-scale generation of mutans and hands-on experience with CRISPR-based methods such as MAGESTIC is also necessary.
A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential.
Good interpersonal skills and ability to work in teams is essential.

Meritorious for the role:

Previous experience in yeast genetics, biochemistry and the study of stress response will be a merit.

In the appointment, special weight will be attached to scientific skill of relevance to the project and to previous research experience.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 2024-10-23.

The application is to be submitted through the Varbi recruitment system.

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