Research Assistant in computational and cell biology

Do you want to contribute to top quality medical research?

Recognition and fusion of the female and male gametes, egg and sperm, marks the beginning of the life of a new individual. Join the research group of Professor Luca Jovine (http://jovinelab.org) and combine cell, structural and computational biology to shed light on a biological event that is not only fundamental from a basic science point of view but has also major implications for the future of human reproductive medicine!

Your mission

We have recently computationally identified a number of protein complexes that are likely to play a key role in gamete fusion (see for example PubMed ID 38666763), and your mission will be to both extend these studies computationally and obtain experimental evidence for some of the suggested biomolecular interactions.

Your profile

Given the dual nature of the project, you should have a Master’s degree and:

(1) Be proficient in computational structural biology, particularly in relation with deep learning-based protein structure prediction by AlphaFold and related software. Working knowledge of the Linux operating system is absolutely essential; experience with molecular graphics programs (PyMOL, Chimera/ChimeraX) and knowledge of Python programming are highly desirable.

(2) Have previous experience of recombinant protein expression and/or mammalian/insect cell culture. Previous knowledge of protein purification is also desirable, but not essential; willingness to learn experimental structural biology — if required by the project — is fundamental.

In addition, you should be generally fluent in English (both written and oral) and have a strong personal drive to excel in science. Emphasis will be put on personal suitability.

What do we offer?

We offer a temporary employment for 12 months.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Flemingsberg

Links for further reading:
Department of Medicine, Huddinge
Choose to work at KI – Ten reasons why

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Application

Welcome to apply at the latest 14 October 2024.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all