Research Engineer in Eukaryotic RNA and Chromatin Genomics

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe.

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes and are passionate about RNA biology (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

Are you interested in unravelling the eukaryotic post-transcriptional regulatory code? Would you like to combine the use of cutting-edge genome-wide technologies with synthetic biology and machine learning to study RNA life? Come and join us at SciLifeLab.

Your mission

The available research engineer position concerns developing and applying novel genomic approaches to study eukaryotic gene expression at an unprecedented scale, combining experimental and computational approaches. The candidate will work in the context of a recently awarded ERC synergy project (EPIC - Unravelling the eukaryotic post-transcriptional regulatory code) in collaboration with the labs of Professor Kevin Verstrepen (Leuven) and Professor Julien Gagneur (Munich). EPIC will combine the use of genomic, synthetic biology, machine learning and evolutionary approaches with the aim to understand the complete gene expression regulatory code of S. cerevisiae and other eukaryotes.

The recruited candidate will focus on mapping and prediction mRNA boundaries at an unprecedented scale. The candidate will also use generate and integrate chromatin information to predict mRNA variations. The candidate will integrate different experimental and computational approaches for the completion of the project, including genomics, yeast genetics, high-throughput biology approaches and bioinformatics. Further, the candidate will perform original research in transcriptomics and computational biology, and acquire the required experimental and computational skills necessary for the completion of the project.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate will participate in the general duties of the team and effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

Your profile

Applicants to this position should have a bachelor’s degree in Biotechnology, Molecular Biology or a similar field.

In addition to the above requirements for the position:

A strong interest in interdisciplinary technology development, and novel and creative thinking abilities
Experience in NGS and bioinformatics
Experience in genetics
Experience in DNA/RNA extraction
Good interpersonal skills and ability to work in teams

Meritorious for the position:

Experience in chromatin biology
Experience in transcription and post-transcriptional mRNA regulation
Experience in genetics across evolutionary related organism
In the appointment, special weight will be attached to scientific skill of relevance to the project and to previous research experience

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna

Choose to work at KI – Ten reasons why

http://pelechanolab.com/

Application

Welcome to apply at the latest 1 September.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Want to make a difference? Join us and contribute to better health for all