Research assistant in RNA regulation of Neisseria meningitidis

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

Dr. Edmund Loh’s group is focusing on RNA-mediated molecular mechanisms that are involved in bacterial pathogenesis. The pathogen of research is Neisseria meningitidis (meningococcus) and we utilise a wide variety of genetic, cell biological and biochemical methods and techniques. The research in Dr. Loh’s group focuses on the regulation of sRNAs and their gene expression patterns during various biological stress conditions.

We are looking for a Research assistant to work on a project on RNA-mediated pili regulation in the meningococcus.

Your mission

In this project, funded by a grant from the Swedish Research Council, we aim to characterise the meningococcal Type four pili regulation mediated by regulatory RNAs. Overall, we aim at unravelling both meningococcal piliation and virulence, as well as the establishment of a microfluidic infection model for the meningococcus.

The research assistant will work with an international research team in an international collaboration to design and conduct research relevant to the research group’s agenda while receiving advanced training to enhance professional skills and research independence. The research assistant’s time will also be devoted to data and database management, analysis, manuscript preparation and career development. The candidate will be asked to collaborate with others, and provide her/his expertise in other projects.

Your profile

Requirements for the position:

The successful candidate has a strong interest and background in bacterial pathogenesis and RNA regulation.
The candidate we are looking for is highly collaborative and generous with sharing her/his knowledge.
The candidate is an independent researcher, with a strong interest in bacterial gene regulation and RNA biology.

In addition to the aforementioned requirements, the applicant must have the following skills:

Key skills include working in a biosafety level 2 plus (BSL-2*) lab, bacterial gene cloning (knock-out, mutagenesis), and manuscript/grant writing.
Extensive knowledge in bacterial gene regulation and RNA biology to independently perform experiments in a BSL-2* lab.
Work experience with meningococcus or other aerosol borne bacterial pathogens.

Additional skills that are meritorious for the position:

Strong presentation skills.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Location: Solna

https://twitter.com/LabLoh

Application

Welcome to apply at the latest 2024-09-02.

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Want to make a difference? Join us and contribute to better health for all