Research engineer

Do you want to contribute to top quality medical research?

The Department of Medical Epidemiology and Biostatistics conducts research in epidemiology and biostatistics across a broad range of areas within biomedical science. The department is among the largest of its type in Europe and has especially strong research profiles in psychiatric, cancer, reproductive, pediatric, pharmaco, genetic, and geriatric epidemiology, eating disorders, precision medicine, and biostatistics.

Part of the success of our department is due to our collaborative spirit where one factor is that researchers at the Department share and co-finance common resources (e.g., IT and an applied biostatistics group). The department is situated at campus Solna. Further information can be found at http://ki.se/en/meb

At the Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, several prospective clinical studies in cancer are ongoing. The Cancer Genomics team at MEB is responsible for prospective analysis of patient material from these clinical trials. These involve >50 hospitals in six European countries. The two largest trials are the ProBio study (www.probiotrial.org) and the ALASCCA study (https://ki.se/mmk/alascca-studien). The team is led by senior researcher Johan Lindberg and is part of a larger research community (~25 people) led by Professor Henrik Grönberg. The ALASCCA study is a collaboration between Anna Martling's research group (Department of Molecular Medicine and Surgery (MMK), KI) and Henrik Grönberg's research group (MEB, KI).

Your mission

Every week samples are sent to KI biobank for the prospective clinical trials. These samples need to be processed and prepared for DNA sequencing in our genomics lab. We are looking for a meticulous person for weekly handling of different types of tissues with the aim of performing advanced DNA analysis.

The position of research engineer includes the following tasks:

1) DNA extraction from plasma, FFPE tissue, whole blood and fresh frozen tissue.

2) Preparation of DNA libraries for sequencing on an Illumina sequencing instrument.

3) To perform enrichment on the DNA library of selected regions of the human genome using

in solution hybridization-based capture.

4) Accurate reporting of the ongoing results of the weekly work according to a protocol.

5) Optimizations of our current protocols. We are constantly looking to improve the assays and bioinformatics software used in the team.

6) To process retrospective samples from collected patient material.

Your profile

Entry requirements

Master of science in relevant subject area and with at least five years of lab experience.
Oral communication skills in English is required as the working environment is international.

Meritorious

Experience of the tasks 1) - 4) above.
Experience of optimizing assays such as PCR or ddPCR.
Experience of basic data analysis in eg. R-studio for evaluation of results from labs.
Experience from working in an accredited lab.
Experience in establishing accreditation for a lab.
PhD if the thesis work encompassed optimizing assays such as PCR or ddPCR.

To succeed in the environment, the candidate must have the ability to work independently, to co-operate, be ambitious and take initiative.

We attach great importance to personal qualities.

What do we offer?

You will learn laboratory processes to perform advanced DNA analysis. You will work in a team of lab engineers, bioinformaticians and academic staff. The environment is creative and encourages further development to ensure your future attractiveness in the labour market.

Furthermore Karolinska Institutet offers a creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Choose to work at KI – Ten reasons why

Location: Solna

Application

Welcome with your application!

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

Permanent position is initiated by a six months trial period.

Want to make a difference? Join us and contribute to better health for all