Postdoctoral Researcher to the research group Signal Transduction

Do you want to contribute to top quality medical research?

We are looking for a highly driven Postdoctoral Researcher with an interest in increasing our understanding in the pathophysiology of metabolic diseases (i.e. MASLD, T2D, obesity) development.

Your mission

The broad goal of this project, long-term is to increase our understanding of the crosstalk between the endocrine pancreas and the liver in the context of metabolic disease. For this, a novel platform based on transplantations of organotypic cultures into the anterior chamber of the eye of recipient mice is to be used. The recruited postdoctoral fellow is to longitudinally study interactions between these two tissues using real-time in vivo microscopy in combination with other endpoints including immunohistochemistry and RNA sequencing. The project strives to generate mechanistic knowledge in the liver-islets crosstalk axis during disease development and to discover innovative therapeutic approaches against diabetes. The successful applicant will join and enhance ongoing efforts in this project.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a Swedish doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The selected applicant needs to have the following qualifications:

PhD degree in relevant research area, i.e. liver biology and/or metabolic syndrome or similar
Experience in liver biology modelling research, MAFLD and 3D primary hepatocyte NPC spheroid generation and culture
Working knowledge on either human and/or mouse islet biology
Animal handling experience and FELASA certificate is required
Demonstrated experience with Bioinformatic tools and analysis, with emphasis on RNA sequencing A basic understanding of in vivo imaging techniques and microtissue transplantation is highly desirable
Self-initiative and ability to work independently as well as part of a cross-functional team
Excellent English proficiency (written and verbal) and project coordination skills

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 25th of June 2024.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all