Postdoctoral Researcher in Insulin nanotechnology/SRP

Do you want to contribute to top quality medical research?

The Strategic Research Programme in Diabetes (SRP Diabetes) at Karolinska Institutet is funding a prestigious fellowship programme for postdoctoral research fellows. The Programme is focused on research in diabetes and its comorbidities. With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research.

Based at Karolinska Institutet, the applicant will undertake a cutting-edge research project and be part of the SRP Diabetes dynamic research environment where several events will be held throughout the year such as high-profile lectures, symposia, internal retreat, etc. which the applicant will attend.

Your mission

Development of DNA nanotechnology-based methods to map and target membrane protein nanodomains in vitro and in vivo.

At the Teixeira lab, we have developed DNA nanotechnology-based approaches to map and target membrane protein nanodomains (e.g. Spratt, Dias et al., Nature Nanotechnology, 2023; Ambrosetti et al, Nature Nanotechnology, 2021; Fang et al, ACS Nano, 2021; Verheyen, Fang et al, Nucleic Acids Research, 2020; Shaw, Lundin, et al, Nat Methods 2014). In this project, the postdoctoral research fellow will investigate the nanoscale spatial organization of insulin receptors in different tissues. This information will be used to develop multivalent insulin variants using DNA- and protein-based self-assembly. The biodistribution and tissue specific effects of different multivalent insulin variants will be mapped in wild type and diabetes models in zebrafish and mice. This work aims to form the basis for the future development of insulin variants with tailored tissue targeting patterns.

Key responsibilities of the selected applicant:

Plan, manage and conduct an agreed academic research project and associated activities
Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Develop research questions, analyse detailed and complex qualitative and/or quantitative data from a variety of sources, and contribute original ideas for new research projects
Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the Principal Investigator
Adapt existing and develop new scientific techniques and experimental protocols to support research
Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews
Formally present your research and represent the research group at internal, national and international conferences and meetings, either with other members of the team or alone.
Informally present your research to the group at established meetings
Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques

Your profile

We are looking for you who have:

The ability to manage your own academic research and associated activities
A strong CV, having published in high impact journals and presented at international meetings
Ability to contribute ideas for new research projects and research income generation
Ability to work with meticulous attention to detail
An enthusiastic interest in diabetes research
Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community
Strong verbal and written communication skills in English
A conscientious and enthusiastic working approach
Excellent planning, organizational and problem-solving skills

In addition, experience in one or several of the following is valued:

DNA nanotechnology, DNA origami
Super-resolution microscopy, especially DNA-PAINT

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Biomedicum

https://ki.se/en/research/groups/nanomedicine-and-spatial-biology-teixeira-lab#tab-start

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

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