Postdoctoral Researcher in molecular sub-phenotyping of obstructive lung disease related to pre-term birth - Hiring in process/Finished, not possible to apply

Do you want to contribute to top quality medical research?

We have an opening for a postdoctoral researcher wishing to join a multidisciplinary systems medicine project investigating the role of premature birth in the development of obstructive lung disease. The successful candidate will be joining a large research team of clinicians, experimental scientists, statisticians and bioinformaticians to investigate the role of early life events in the development of early onset obstructive lung disease.

Your mission

The overall project involves molecular characterization at the mRNA, miRNA, proteome and metabolome level from multiple lung compartments to construct a model of disease. The work will be conducted on one or several unique clinical cohorts designed to investigate different aspects of chronic obstructive airways disease, including but not limited to our newly launched post-COVID cohort, as well as our the LUNAPRE cohort (www.clinicaltrials.gov/ct2/show/NCT02923648). The latter consisting of very prematurely born individuals with or without bronchopulmonary dysplasia (BPD) in the neonatal period that have been followed since birth, as well as control groups of healthy and asthmatics born at term. The overall goals of these projects involve molecular sub-phenotyping and mechanistic investigations of the obstructive lung disease in this heterogeneous, relatively unknown, and rapidly growing patient group. The specific research projects will include RNA-seq, miRNA-seq and proteome characterizations of various compartments including single cell- or bulk sorted immune cells and extracellular vesicles from the lung of the patient cohort, as well as cell culture lung organoid model systems. The studies are performed in close collaboration with clinicians at both the Karolinska University Hospital and Sach’s Children’s Hospital at the Southern Hospital in Stockholm, enabling the successful candidate to be directly involved in translational systems medicine efforts.

Your profile

We are seeking a talented and highly motivated researcher with a Ph.D. in molecular biology or a related field, for a postdoctoral position in our lab. Practical experience within the respiratory field, coupled with expertise in bioinformatics and biostatistics, is crucial. Hands-on experience in working with human and animal samples, lung organoid work, analysis of PExA samples, and CRISPR-mediated gene editing are highly desirable. The successful candidate must possess excellent communication and collaborative skills; a demonstrated ability to interact socially and scientifically with other postdocs, students, and collaborators both within academia and industry is essential. Previous postdoctoral experience and a strong publication record within the respiratory biology field are strong merits.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location

The position is located within the Department of Medicine, Solna. The department consists of twelve divisions and each division consists of several research groups. The position is located within the Pulmonomics group which is a multidisciplinary research group, located at BioClinicum. As part of the Division of Respiratory Medicine, we are in integral part of the Center for Molecular Medicine (CMM), the Department of Medicine Solna as well as the Karolinska University hospital Department of Allergy and Respiratory Medicine. Our research interests can be broadly defined as developing a respiratory systems medicine framework for molecular sub-grouping of chronic inflammatory diseases of the lung. We focus equal efforts on translational studies in patient cohorts, and innovation & methodology development in the fields proteomics, multivariate modeling and data integration. Our translational systems medicine studies encompass profiling at multiple molecular levels (mRNA, miRNA, proteomes, metabolomes and lipid mediators) from multiple lung compartments (airway epithelium, alveolar macrophages, exosomes, and bronchoalveolar exudates) using a range of omics platforms, in combination with extensive clinical phenotyping. The strength of our approaches is the ability to integrate information from multiple molecular levels and anatomical locations both to improve the statistical power of detecting and defining molecularly distinct sub-groups in small patient cohorts, and to improve our understanding of disease mechanisms on a systems level.

Read more at  https://staff.ki.se/people/asa-wheelock or www.pulmonomics.net 

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Application

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

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