Postdoctoral Researcher in RNA biology

Do you want to contribute to top quality medical research?

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The Pelechano laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe.

Our group combines experimental and computational work and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes and are passionate about RNA biology (http://pelechanolab.com/). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

Are you interested in mRNA fate and localization? Would you like to develop cutting-edge genome-wide technologies to study RNA localization, translation and increase our understanding of RNA life? Come and join us at SciLifeLab.

Your mission

The available postdoctoral position concerns developing and applying novel approaches to study gene expression and RNA localization, both computational and wet-lab. The candidate will focus on the development of novel RNA methods for the understanding of subcellular localization and the role of RNA binding proteins on this process at bulk and single-cell level.

The candidate will integrate different experimental and computational approaches for the completion of the project, including microscopy, biochemistry, NGS and bioinformatics. The candidate will perform original research in transcriptomics and computational biology, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate will participate in the general duties of the team and effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Applicants to this position should have a PhD in Molecular biology, Biotechnology, Genetics or similar field.

In addition to the aforementioned requirements, the applicant must have:

The successful applicant should have experience interpreting biological data and experimentally testing their hypothesis with a strong interest in interdisciplinary technology development.
Suitable candidates should have extensive experience with molecular biology methods such as RNA-Seq, iCLIP, molecular cloning, cultivation of animal cells and immunochemistry in the RNA biology field.
Research experience with large-scale analyses and bioinformatics (NGS, RNA variant analysis, Python, batch and/or R scripting languages) is also necessary.
A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential.
Good interpersonal skills and ability to work in teams is essential.

Meritorius for the position:

Previous experience in RNA editing and RNA binding proteins will a merit.

In the appointment, special weight will be attached to scientific skill of relevance to the project and to previous research experience.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

http://pelechanolab.com/

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply at the latest 2023-12-06.

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all