Postdoctoral Researcher in single cell splicing analyses of the brain

Do you want to contribute to top quality medical research?

Description of the research group

A postdoctoral research position is available in the lab of Rickard Sandberg at the institution for Cell and Molecular Biology (CMB). The lab is located in Biomedicum, a top-notch research building with a modern infrastructure and equipment. Rickard’s lab has focused on developing single-cell technologies to study transcriptional regulation and more recently expanded into post-transcriptional regulation. The lab is equally well represented by experimental and computational researchers, and we carry out all aspects of projects within the lab and also with collaborations. We have developed a unique automated robotic lab for high-capacity full-length scRNA-seq that can splicing-resolution single-cell RNA-seq data across complex tissues that we are starting to use to map out how alternative splicing of neurons is established during development.

Your mission

Your mission

This postdoctoral research project is focused on driving the project on generating unique new data on how and when alternative splicing is specified in the nervous system, to decipher fundamental rules about the splicing code of the brain. The postdoctoral researcher will have a project in collaboration with Allen Brain Inst and Harvard to generate a unique data set with 1 million full-length scRNA-seq profiles using Smart-seq3xpress from various stages of mouse brain development. The successful applicant will be responsible for operating a highly automated molecular biology setup for single-cell genomics, including FACS sorting cells, supervising the robotic infrastructure, and sequencing the libraries on in-house sequencing machines. The lab is surrounded by top-notch neuroscience labs and additional focused research collaborations using transgenic mice will also be possible.

Your profile

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

The postdoctoral candidate must have a background in molecular biology and/or neurobiology. Meriting is experience with sequencing-based projects and single-cell genomics. The successful candidate is expected to have a strong track record in science (including publications) and good communication skills.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Stockholm

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Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.

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